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CORO1B Antibody

  • 货号：
    CSB-PA880087LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA880087LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA880087LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA880087LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CORO1B Polyclonal antibody
  • Uniprot No.：
    Q9BR76
  • 基因名：
    CORO1B
  • 别名：
    COR1B_HUMAN antibody; CORO 1B antibody; CORO1B antibody; Coronin 1B antibody; Coronin 2 antibody; Coronin actin binding protein 1B antibody; Coronin-1B antibody; Coronin-2 antibody; Coronin1B antibody; Coronin2 antibody; DKFZP762I166 antibody; OTTHUMP00000236823 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Coronin-1B protein (252-453AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CORO1B Antibody (CSB-PA880087LA01HU)，的标记方式是Non-conjugated。对于CORO1B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA880087LB01HU CORO1B Antibody, HRP conjugated ELISA
    FITC CSB-PA880087LC01HU CORO1B Antibody, FITC conjugated
    Biotin CSB-PA880087LD01HU CORO1B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction.
  • 基因功能参考文献：
    1. VEGF-activated p38alpha phosphorylates coronin 1B at Ser2 and activates the Arp2/3 complex by liberating it from coronin 1B. PMID: 27592029
    2. Coronin 1B constitutively binds to TGF beta receptor I in vascular smooth muscle cells. PMID: 28625921
    3. The loss of junctional NMIIA, upon Coronin 1B knockdown, perturbed RhoA signaling. PMID: 27650961
    4. When cells undergo apoptosis in an epithelial monolayer, coronin 1B is recruited to the junctional cortex at apoptotic/neighbor cell interface in an E-cadherin-dependent fashion to support actin architectural reorganization, contractility, and extrusion. PMID: 27046832
    5. Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis. PMID: 23667561
    6. analysis of the mechanism for negatively regulating Rho-kinase (ROCK) signaling through Coronin1B protein in neuregulin 1 (NRG-1)-induced tumor cell motility PMID: 22563075
    7. Coronin 1B regulates leading edge dynamics and controls cell motility and interactions with the actin-related protein (Arp)2/3 complex PMID: 16027158
    8. Study concludes that Coronin 1B's coordination of filament formation by Arp2/3 complex and filament turnover by Cofilin is required for effective lamellipodial protrusion and cell migration. PMID: 17350576
    9. In rabbits, cholinergic stimulation increases the phosphorylation of coronin 1B in gastric mucosal cells PMID: 9915840

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber.
  • 蛋白家族：
    WD repeat coronin family
  • 数据库链接：

    HGNC: 2253

    OMIM: 609849

    KEGG: hsa:57175

    STRING: 9606.ENSP00000340211

    UniGene: Hs.6191