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COX15 Antibody

  • 货号：
    CSB-PA007199
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q7KZN9
  • 基因名：
  • 别名：
    CEMCOX2 antibody; COX15 antibody; COX15 homolog; cytochrome c oxidase assembly protein antibody; COX15; S. cerevisiae; homolog of antibody; COX15_HUMAN antibody; cytochrome c oxidase assembly homolog 15 (yeast) antibody; Cytochrome c oxidase assembly protein COX15 homolog antibody; cytochrome c oxidase subunit 15 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human COX15.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in the biosynthesis of heme A.
  • 基因功能参考文献：
    1. Mutations of COX15 causing single amino acid conversions are associated with fatal infantile hypertrophic cardiomyopathy and the neurological disorder Leigh syndrome. PMID: 26940873
    2. Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy PMID: 12474143
    3. A patient with typical clinical and neuroradiological features of Leigh syndrome and cytochrome oxidase deficiency was found to have a mutation in the COX15 gene. PMID: 15235026
    4. cdkl3 transfected in anchorage-independent (suspension) HeLa cells overexpressed relative to attached cells and lead to elevated proliferation and viability relative to untransfected. Same in two HEK-293 and a CHO cell lines. PMID: 17945021
  • 相关疾病：
    Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 2 (CEMCOX2); Leigh syndrome (LS)
  • 亚细胞定位：
    Mitochondrion membrane; Multi-pass membrane protein.
  • 蛋白家族：
    COX15/CtaA family
  • 组织特异性：
    Predominantly found in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
  • 数据库链接：

    HGNC: 2263

    OMIM: 256000

    KEGG: hsa:1355

    STRING: 9606.ENSP00000016171

    UniGene: Hs.28326