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COX8A Antibody

  • 货号：
    CSB-PA778289
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA778289(COX8A Antibody) at dilution 1/12, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA778289(COX8A Antibody) at dilution 1/12, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P10176
  • 基因名：
  • 别名：
    COX antibody; COX8 antibody; COX8-2 antibody; COX8A antibody; COX8A_HUMAN antibody; COX8L antibody; Cytochrome c oxidase polypeptide VIII-liver/heart antibody; Cytochrome c oxidase subunit 8-2 antibody; Cytochrome c oxidase subunit 8A (ubiquitous) antibody; Cytochrome c oxidase subunit 8A antibody; Cytochrome c oxidase subunit 8A, mitochondrial antibody; Cytochrome c oxidase subunit VIII antibody; Cytochrome c oxidase subunit VIIIA (ubiquitous) antibody; mitochondrial antibody; VIII antibody; VIII-L antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human COX8A
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:10-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
  • 基因功能参考文献：
    1. COX8A is indispensable for function of human complex IV and its mutation causes Leigh-like syndrome and epilepsy. PMID: 26685157
  • 亚细胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族：
    Cytochrome c oxidase VIII family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 2294

    OMIM: 123870

    KEGG: hsa:1351

    STRING: 9606.ENSP00000321260

    UniGene: Hs.743989