CPEB3 Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) CPEB3 Polyclonal antibody
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Uniprot No.:Q8NE35
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基因名:CPEB3
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别名:CPE-binding protein 3 antibody; CPE-BP3 antibody; CPEB 3 antibody; CPEB3 antibody; CPEB3_HUMAN antibody; Cytoplasmic polyadenylation element binding protein 3 antibody; Cytoplasmic polyadenylation element-binding protein 3 antibody; hCPEB-3 antibody; KIAA0940 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human Cytoplasmic polyadenylation element-binding protein 3 protein (414-525AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,CPEB3 Antibody (CSB-PA818773LA01HU),的标记方式是Non-conjugated。对于CPEB3 Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, IF
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推荐稀释比:
Application Recommended Dilution IF 1:50-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure. Required for the consolidation and maintenance of hippocampal-based long term memory. In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their ...显示更多
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基因功能参考文献:
- Overexpression of miR-452-3p promoted cell proliferation and mobility and suppressed apoptosis. MiR-452-3p enhanced EGFR and phosphorylated AKT (pAKT) expression but inhibited p21 expression level. MiR-452-3p promoted hepatocellular carcinoma (HCC)cell proliferation and mobility by directly targeting the CPEB3/EGFR axis PMID: 29332449
- Data show that the expression of cytoplasmic polyadenylation element binding protein 3 (CPEB3) positively correlated with tumor progression and malignancy but negatively correlated with protein phosphorylation in the alternatively spliced region. PMID: 27256982
- Data show that EGF receptor (EGFR) is involved in the microRNA miR-107 pathogenesis of hepatocellular carcinoma (HCC) through cytoplasmic polyadenylation element binding protein 3 (CPEB3). PMID: 26497556
- Data suggest that the RNA recognition motif (RRM) domain of CPEB3 (as a soluble peptide fragment) exhibits protein conformation distinct from those of the canonical RRM domain. PMID: 25066254
- cleavage of CPEB3 by NMDA-activated calpain 2 accounts for the activity-related translation of CPEB3-targeted RNAs PMID: 22711986
- Secondary structure determination and native gel analyses reveal that the cleaved population of the CPEB3 ribozyme has a single, secondary structure that closely resembles the HDV ribozyme PMID: 20524672
- isolation of a ribozyme conserved mammalian sequence that resides in an intron of the CPEB3 gene PMID: 16990549
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亚细胞定位:Cytoplasm. Nucleus. Cell junction, synapse. Cell projection, dendrite. Cell junction, synapse, postsynaptic density.
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蛋白家族:RRM CPEB family
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数据库链接:
HGNC: 21746
OMIM: 610606
KEGG: hsa:22849
STRING: 9606.ENSP00000265997
UniGene: Hs.131683