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CPLX1 Antibody

  • 货号：
    CSB-PA005893LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA005893LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA005893LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CPLX1 Polyclonal antibody
  • Uniprot No.：
    O14810
  • 基因名：
  • 别名：
    921-S antibody; complexin 1 antibody; Complexin I antibody; Complexin-1 antibody; CPLX1 antibody; CPLX1_HUMAN antibody; CPX I antibody; CPX-I antibody; CPX1 antibody; Synaphin 2 antibody; Synaphin-2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Complexin-1 protein (1-134AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CPLX1 Antibody (CSB-PA005893LA01HU)，的标记方式是Non-conjugated。对于CPLX1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA005893LB01HU CPLX1 Antibody, HRP conjugated ELISA
    FITC CSB-PA005893LC01HU CPLX1 Antibody, FITC conjugated
    Biotin CSB-PA005893LD01HU CPLX1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.
  • 基因功能参考文献：
    1. data define CPLX1 as a PD risk factor and provide functional insights into the role and regulation of blood SNCA levels. The new blood biomarkers of PARK4 in this Turkish family might become useful for PD prediction PMID: 28108469
    2. Homozygous CPLX1 variants were identified in three patients with severe infantile myoclonic epilepsy and ID. PMID: 28422131
    3. This study demonstrated that complexin-I influence cognitive function in early and late stages of Alzheimer's disease. PMID: 27866231
    4. Study showed for the first time that neuro-Behcet's disease and Behcet's disease patients are inclined to display the GG genotype of the CPLX1 rs936551 polymorphism and to exhibit increased CPLX1 expression levels PMID: 26577184
    5. Collectively these results demonstrate that CPX-1 is a secreted collagen-binding glycoprotein and provide a foundation for future studies investigating the function of CPX-1. PMID: 26603934
    6. Studies indicate the role of the small regulatory factor complexin in Ca(2+)-dependent vesicle fusion and exocytosis. PMID: 26245303
    7. Data support the the trans insertion model for complexin clamping. PMID: 25831964
    8. Together with synaptotagmin 1, complexin synchronizes and stimulates rapid fusion of accumulated docked vesicles in response to physiological Ca(2+) concentrations. PMID: 22705946
    9. The crystal structure of complexin bound to a prefusion SNAREpin mimetic shows that the accessory helix extends away from the SNAREpin in an 'open' conformation, binding another SNAREpin and inhibiting its assembly, to clamp fusion. PMID: 21785412
    10. The 'central helix' of complexin is anchored to one SNARE complex, while its 'accessory helix' extends away at ~45 degrees and bridges to a second complex, occupying the vacant v-SNARE binding site to inhibit fusion. PMID: 21785414
    11. description of what may represent a basic principle of the coupling mechanism in SNARE dependent exocytosis: a reversible clamping protein, complexin, that can freeze the SNAREpin, an assembled fusion-competent intermediate en route to fusion PMID: 16794037
    12. CX1 level increased progressively across development PMID: 18240322

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  • 亚细胞定位：
    Cytoplasm, cytosol. Perikaryon. Cell junction, synapse, presynapse.
  • 蛋白家族：
    Complexin/synaphin family
  • 组织特异性：
    Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease.
  • 数据库链接：

    HGNC: 2309

    OMIM: 605032

    KEGG: hsa:10815

    STRING: 9606.ENSP00000305613

    UniGene: Hs.478930