Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. CPNE1 Antibody

CPNE1 Antibody

  • 货号：
    CSB-PA859524LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA859524LA01HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CPNE1 Polyclonal antibody
  • Uniprot No.：
    Q99829
  • 基因名：
    CPNE1
  • 别名：
    Copine 1 antibody; Copine I antibody; Copine-1 antibody; Copine1 antibody; CopineI antibody; COPN 1 antibody; COPN1 antibody; CPN 1 antibody; CPN1 antibody; CPNE 1 antibody; CPNE1 antibody; CPNE1_HUMAN antibody; MGC1142 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Copine-1 protein (326-537AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CPNE1 Antibody (CSB-PA859524LA01HU)，的标记方式是Non-conjugated。对于CPNE1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA859524LB01HU CPNE1 Antibody, HRP conjugated ELISA
    FITC CSB-PA859524LC01HU CPNE1 Antibody, FITC conjugated
    Biotin CSB-PA859524LD01HU CPNE1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL.
  • 基因功能参考文献：
    1. Results demonstrated that CPNE1 was highly expressed in the osteosarcoma (OS) tissues and cell lines. Its knockdown significantly inhibited cell proliferation, colony formation, invasion and metastasis in OS cell lines. PMID: 29207139
    2. CPNE1 overexpression can upregulate TRAF2 expression in prostate cancer DU-145 cells as determined by Western blotting and immunofluorescence assays. PMID: 29151113
    3. Collectively, our findings suggest that JAB1 activates the neuronal differentiation ability of CPNE1 through the binding of C2A domain in CPNE1 with MPN domain in JAB1. PMID: 29448099
    4. Copine I regulates tumour necrosis factor-alpha receptor signaling pathways. PMID: 14674885
    5. Copine1 is upregulated in plasma membranes of TM cells in individuals with primary open-angle glaucoma. PMID: 18523666
    6. CPNE1 shares a promoter and 5'UTR exons with RBM12. This genomic structure is conserved among multiple species. PMID: 18831769

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell membrane.
  • 蛋白家族：
    Copine family
  • 组织特异性：
    Expressed in neutrophils (at protein level). Widely expressed. Expressed in the brain. Expressed in neutrophil precursors from bone marrow and peripheral blood.
  • 数据库链接：

    HGNC: 2314

    OMIM: 604205

    KEGG: hsa:8904

    STRING: 9606.ENSP00000317257

    UniGene: Hs.246413