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CPSF4 Antibody

  • 货号：
    CSB-PA005919GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O95639
  • 基因名：
    CPSF4
  • 别名：
    cleavage and polyadenylation specific factor 4; 30kDa antibody; Cleavage and polyadenylation specificity factor 30 kDa subunit antibody; Cleavage and polyadenylation specificity factor subunit 4 antibody; cleavage polyadenylation specificity factor; 30kD antibody; CPSF 30 kDa subunit antibody; CPSF30 antibody; Cpsf4 antibody; CPSF4_HUMAN antibody; NAR antibody; Neb-1 antibody; NEB1 antibody; No arches homolog antibody; no arches like zinc finger protein antibody; NS1 effector domain binding protein 1 antibody; NS1 effector domain-binding protein 1 antibody; OTTHUMP00000206235 antibody; OTTHUMP00000206237 antibody; OTTHUMP00000206239 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CPSF4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
  • 基因功能参考文献：
    1. The s define the molecular architecture of the core human CPSF complex comprising CPSF160, WDR33, CPSF30 and Fip1 and identify specific domains involved in inter-subunit interactions. Together, these results shed light on the function of CPSF in mediating polyA signal-dependent RNA cleavage and polyadenylation. PMID: 29274231
    2. Residues F103 and M106 within the NS1-CPSF4 binding region are important for viral replication. PMID: 28554059
    3. Cleavage and polyadenylation specific factor 4 targets NF-kappaB/cyclooxygenase-2 signaling to promote the growth and survival of non-small cell lung carcinoma cells. PMID: 27450326
    4. These findings support a role for iron in some zinc-finger proteins. Using electrophoretic mobility shift assays and fluorescence anisotropy, we report that CPSF30 selectively recognizes the AU-rich hexamer (AAUAAA) sequence present in pre-mRNA, providing the first molecular-based evidence to our knowledge for CPSF30/RNA binding. PMID: 27071088
    5. unexpectedly found that CPSF subunits CPSF30 and Wdr33 directly contact AAUAAA PMID: 25301780
    6. CPSF4 upregulates human TERT promoter activity, human TERT expression and telomerase activity. PMID: 24618080
    7. Data show that 4 drug-like compounds from traditional Chinese Medicine (TCM) database were selected as potential inhibitors for the cleavage and polyadenylation specific factor CPSF30-binding site of influenza A virus of non-structural protein 1 (NS1A). PMID: 24562912
    8. CPSF4 plays a critical role in regulating lung cancer cell proliferation and survival and may be a potential prognostic biomarker and therapeutic target for lung adenocarcinoma. PMID: 24358221
    9. Data show that the NS1A protein of the pathogenic H5N1 influenza A/Hong Kong/483/97 (HK97) virus isolated from humans has an intrinsic defect in CPSF30 binding. PMID: 17522219

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    CPSF4/YTH1 family
  • 数据库链接：

    HGNC: 2327

    OMIM: 603052

    KEGG: hsa:10898

    STRING: 9606.ENSP00000292476

    UniGene: Hs.489287