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CRCP Antibody

  • 货号：
    CSB-PA005945LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA005945LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA005945LA01HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA005945LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CRCP Polyclonal antibody
  • Uniprot No.：
    O75575
  • 基因名：
    CRCP
  • 别名：
    Calcitonin gene related peptide receptor component antibody; Calcitonin gene related peptide receptor component protein antibody; Calcitonin gene-related peptide-receptor component protein antibody; CGRP receptor component protein antibody; CGRP-RCP antibody; CGRP-receptor component protein antibody; CGRPRCP antibody; CRCP antibody; DNA-directed RNA polymerase III subunit RPC9 antibody; HsC17 antibody; RCP antibody; RCP9 antibody; RNA polymerase III subunit C9 antibody; RPC9_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human DNA-directed RNA polymerase III subunit RPC9 protein (1-115AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CRCP Antibody (CSB-PA005945LA01HU)，的标记方式是Non-conjugated。对于CRCP Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA005945LB01HU CRCP Antibody, HRP conjugated ELISA
    FITC CSB-PA005945LC01HU CRCP Antibody, FITC conjugated
    Biotin CSB-PA005945LD01HU CRCP Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway.; Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.
  • 基因功能参考文献：
    1. data reinforce and clarify our understanding of CGRP receptor localization, and provide evidence that antagonist antibodies bind to target sites in the trigeminovascular system of primates that are involved in the pathology of migraine PMID: 27155150
    2. CGRP family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas, Galphai, and Galphaq/11 pathways. PMID: 27566546
    3. In this review, the influence of the CGRP family peptides in reproduction and pregnancy is explored and discussed. PMID: 25015815
    4. This study demonstrates the detailed expression of CGRP and its receptor components within spinal trigeminal nucleus in the brainstem and in the spinal cord at C1-level PMID: 22074408
    5. The extracellular protein domains corresponding to residues 23-133 of calcitonin receptor-like receptor and residues 26-117 of receptor activity-modifying protein 1 (RAMP1) are shown to be sufficient for formation of a stable, folded monodisperse complex. PMID: 20099900
    6. Expression of CGRP-RCP was detected in CD34+ cells and also in some mature granulocyte samples, providing evidence that CGRP-RCP may be regulated independently of RAMP1 and CRLR in hematopoietic cells. PMID: 11937264
    7. human CGRP-RCP is the genuine orthologue of C17. CGRP-RCP was found to functionally replace C17 in Deltarpc17 yeast cells; CGRP-RCP was identified in a purified human Pol III preparation. PMID: 12482973
    8. inhibition of ACE seems to augment CGRP catabolism. PMID: 16406141
    9. Increased mRNA expression CGRP-RCP in gravid myometrium supports the possibility of involvement of CGRP in the control of myometrial contractility. PMID: 17853344
    10. A peptide mimetic demonstrates that 12 residues of family B member CGRP receptor proximal C-terminus are required for this receptor's expression and localization at the cell membrane. PMID: 18636754
    11. analysis of the effects of antagonists to the CGRP receptor PMID: 19053766

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  • 亚细胞定位：
    Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Eukaryotic RPC9 RNA polymerase subunit family
  • 组织特异性：
    Ubiquitous. Most prevalent in testis.
  • 数据库链接：

    HGNC: 17888

    OMIM: 606121

    KEGG: hsa:27297

    STRING: 9606.ENSP00000378736

    UniGene: Hs.300684