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  4. CREB3L4 Antibody

CREB3L4 Antibody

  • 货号：
    CSB-PA005952GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8TEY5
  • 基因名：
  • 别名：
    1700012K17Rik antibody; AIbZIP antibody; Androgen induced basic leucine zipper antibody; Androgen induced basic leucine zipper protein antibody; Androgen-induced basic leucine zipper protein antibody; ATCE1 antibody; Attaching to CRE like 1 antibody; Attaching to CRE-like 1 antibody; cAMP responsive element binding protein 1 antibody; cAMP responsive element binding protein 3 like 4 antibody; cAMP responsive element binding protein 4 antibody; cAMP responsive element-binding protein 3 like protein 4 antibody; cAMP-responsive element-binding protein 3-like protein 4 antibody; cAMP-responsive element-binding protein 4 antibody; CR3L4_HUMAN antibody; CREB 4 antibody; CREB-4 antibody; CREB3 antibody; CREB3L4 antibody; CREB4 antibody; Cyclic AMP responsive element binding protein 3 like protein 4 antibody; Cyclic AMP responsive element binding protein 4 antibody; Cyclic AMP-responsive element-binding protein 4 antibody; hJAL antibody; JAL antibody; mJAL antibody; Processed cyclic AMP-responsive element-binding protein 3-like protein 4 antibody; Tisp40 antibody; Tisp40alpha antibody; Tisp40beta antibody; Transcript induced in spermiogenesis protein 40 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human CREB3L4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements.
  • 基因功能参考文献：
    1. CREB3L4 expression is mediated by an androgen-receptor -IRE1alpha axis, but is also directly regulated by androgen-receptor-to-androgen response elements binding. PMID: 28338058
    2. AIbZIP induced by the androgen receptor axis plays a crucial role in the p21 dependent proliferation of androgen-sensitive prostate cancer cells. PMID: 27853318
    3. AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells. PMID: 11830526
    4. identified a novel human CREB gene (CREB4) that was 1592 bp long and encoded a protein of 395 amino acid residues PMID: 12111373
    5. S1P cleavage of CREB4 may be suppressed by a determinant in the C-terminal region PMID: 16236796
    6. In LNCaP cell lines that conditionally express the processed form of AIbZIP, downstream targets of AIbZIP include genes for protein processing, transcriptional regulation, small molecule transport, signal transduction, metabolism & cell homeostasis. PMID: 17712038

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    BZIP family, ATF subfamily
  • 组织特异性：
    According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than
  • 数据库链接：

    HGNC: 18854

    OMIM: 607138

    KEGG: hsa:148327

    STRING: 9606.ENSP00000271889

    UniGene: Hs.372924