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CSDE1 Antibody

  • 货号：
    CSB-PA006040LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry analysis of human kidney tissue using CSB-PA006040LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA006040LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CSDE1 Polyclonal antibody
  • Uniprot No.：
    O75534
  • 基因名：
  • 别名：
    Cold shock domain containing E1 RNA binding antibody; Cold shock domain containing protein E1 antibody; Cold shock domain-containing protein E1 antibody; Csde1 antibody; CSDE1_HUMAN antibody; D1S155E antibody; DKFZp779B0247 antibody; DKFZp779J1455 antibody; FLJ26882 antibody; N-ras upstream gene protein antibody; NRAS related antibody; Nras upstream gene protein antibody; NRU antibody; Protein UNR antibody; RP5 1000E10.3 antibody; UNR antibody; UNR protein antibody; Upstream of NRAS antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cold shock domain-containing protein E1 protein (433-630AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CSDE1 Antibody (CSB-PA006040LA01HU)，的标记方式是Non-conjugated。对于CSDE1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA006040LB01HU CSDE1 Antibody, HRP conjugated ELISA
    FITC CSB-PA006040LC01HU CSDE1 Antibody, FITC conjugated
    Biotin CSB-PA006040LD01HU CSDE1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    RNA-binding protein involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Required for efficient formation of stress granules.; (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA.
  • 基因功能参考文献：
    1. CSDE1 post-transcriptionally modulates core components of multiple regulatory nodes of human embryonic stem cell identity, neuroectoderm commitment and neurogenesis and acts as a negative regulator of neural differentiation and neurogenesis. PMID: 29129916
    2. UNR/CDSE1 expression is correlated with outcome in patients with resectable pancreatic ductal adenocarcinoma PMID: 28763470
    3. Results identify UNR as an oncogenic modulator of melanoma progression, unraveling the underlying molecular mechanisms. UNR seems to regulate translation elongation of Vimentin and RAC1 mRNAs. PMID: 27908735
    4. Studies indicate that Unr (upstream of N-ras) is post-translationally modified by phosphorylation and lysine acetylation. PMID: 26614667
    5. Hepsin suppressed CDK11p58 internal ribosome entry site activity in prostate cancer cells by modulating UNR expression and eIF-2alpha phosphorylation. PMID: 25576733
    6. Study suggests TRIM33 and NRAS-CSDE1 as candidate genes for autism, and may provide a novel insight into the etiology of autism PMID: 24189344
    7. unr and nPTB act as RNA chaperones by changing the structure of the IRES into one that permits translation initiation PMID: 12667457
    8. UNR translation is regulated by an internal ribosome entry site that is downregulated by polypyrimidine tract binding protein. PMID: 15928332
    9. regulation of IRES-mediated translation by hnRNP C1/C2 and Unr might be important in mitosis PMID: 17159903
    10. The data suggest that Unr acts as an RNA chaperone on rhinovirus RNA 5' UTR to maintain a complex tertiary internal ribosome entry site structure required for translational competency. PMID: 17947529

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, P-body.
  • 数据库链接：

    HGNC: 29905

    OMIM: 191510

    KEGG: hsa:7812

    STRING: 9606.ENSP00000407724

    UniGene: Hs.69855