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CSNK2B Antibody

  • 货号：
    CSB-PA099774
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA099774(CSNK2B Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA099774(CSNK2B Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P67870
  • 基因名：
  • 别名：
    Casein kinase 2 beta polypeptide antibody; Casein kinase II beta subunit antibody; Casein kinase II subunit beta antibody; CK II beta antibody; CK2B antibody; CK2N antibody; CSK2B antibody; CSK2B_HUMAN antibody; CSNK 2B antibody; csnk2b antibody; G5A antibody; MGC138222 antibody; MGC138224 antibody; Phosvitin antibody; Protein G5a antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human CSNK2B
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
  • 基因功能参考文献：
    1. Patients described are the first cases presenting a loss-of-function variant in the CSNK2B gene in the context of intellectual disability (ID), suggesting that CSNK2Bvariants can cause ID. PMID: 28585349
    2. ALMS1, GLT8D1, and CSNK2B are schizophrenia risk genes. PMID: 29483533
    3. We report interactions between CSNK-2beta and IGFBP-1 as well as mTOR and CSNK-2beta, providing strong evidence of a mechanistic link between mTOR and IGF-I signaling, two critical regulators of cell growth via CSNK-2. PMID: 29037858
    4. Casein kinase 2 role in the proliferation of human osteosarcoma cells. PMID: 27959425
    5. Data suggest that cryptochromes (Cry1 and Cry2) mediate periodic binding of Ck2b (casein kinase 2beta) to Bmal1 (aryl hydrocarbon receptor nuclear translocator-like protein) and thus inhibit Bmal1-Ser90 phosphorylation by Ck2a (casein kinase 2alpha). PMID: 26562092
    6. AMPKalpha signalling suppresses EMT and secretion of chemokines in renal tubular epithelia through interaction with CK2beta to attenuate renal injury. PMID: 26108355
    7. ARKL1 binds CK2beta through the KSSR motif and this involves a polyserine sequence resembling the CK2beta binding sequence in EBNA1. PMID: 24216761
    8. The high expression of protein kinase CK2beta is closely related to the carcinogenesis and malignancy of esophageal cancer. PMID: 23076192
    9. The high expression of ck2beta in colorectal cancer is closely correlated to carcinogenesis and metastasis. PMID: 21515457
    10. A dysregulation of CK2beta expression might contribute to epithelial-to-mesenchymal-transition induction during cancer progression. PMID: 21755461
    11. C-terminal domain of PLD2 can regulate CKII by accelerating CKIIbeta degradation in HCT116 cells PMID: 21944249
    12. Our findings argue against the hypothesis that genetic variability in the G-Protein-Coupled Receptor Kinase 5 and Casein Kinase 2 genes modifies Parkinson disease susceptibility PMID: 21514207
    13. CK2 enhances the protein level and activity of TTP via the modulation of the MKP-1-p38 MAPK signaling pathway; TGF-beta1 enhances the activity of CK2 PMID: 21507959
    14. Identification of key residues on CK2alpha and CK2beta that play a cooperative role in CK2alpha/CK2beta binding and thermodynamics is important to further understand how these subunits interact in order to form a tetramer. PMID: 21142136
    15. Threonine at amino acid (aa) 770 and serine at aa 854 to 855 of RIG-I are phosphorylated by casein kinase II (CK2) in the resting state of the cell and dephosphorylated when cells are infected by RNA virus. PMID: 21068236
    16. analysis of interaction sites between Wee1 kinase and the regulatory beta-subunit of protein kinase CK2 PMID: 20372791
    17. Freshly isolated peripheral blood mononuclear cells from patients with chronic lymphocytic leukemia (n = 44) showed significantly higher levels of phosphorylated Akt1,PTEN, and casein kinase 2 than healthy persons (n = 8). PMID: 20576813
    18. CK2 could phosphorylate TNFAIP1 in vitro and in vivo, which facilitated the distribution of TNFAIP1 in nucleus and enhanced its interaction with PCNA. PMID: 19851886
    19. The Casein Kinase 2 (CK2) was identified as a binding and regulatory partner for Mitogen- and stress-activated protein kinase(MSK1). PMID: 20044958
    20. Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins. PMID: 11710515
    21. Protein kinase CK2 dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TRCp and enhances beta-catenin degradation. PMID: 12037680
    22. sequencing of full-length DNA encoding subunits in platelets and megakaryocytic cells PMID: 12102635
    23. FGF-1 binds to both the catalytic alpha-subunit & to the regulatory beta-subunit of CK2.The presence of FGF-1 or FGF-2 was found to enhance the autophosphorylation of CK2 beta. PMID: 12145206
    24. results show that the Ring-H2 finger motif of CKBBP1 is necessary for efficient binding to CKIIbeta, as well as for optimal cell proliferation PMID: 12470599
    25. microtubule-associated protein that confers microtubule stability in a phosphorylation-independent manner PMID: 14634006
    26. Casein kinase II (CKII) phosphorylates synphilin-1; beta subunit of this enzyme complex binds to synphilin-1. CKII-mediated phosphorylation of synphilin-1, rather than alpha-synuclein, modulates the aggregation into inclusion bodies. PMID: 14645218
    27. CK2 phosphorylation of La can affect production of the translational machinery PMID: 15485924
    28. These findings support the notion that CK2beta can act as a general modulator of remote docking sites in protein kinase--substrate interactions. PMID: 15940255
    29. there is a functional link between S6K1 II and CK2 signaling, which involves the regulation of S6K1 II nuclear export by CK2-mediated phosphorylation of Ser-17 PMID: 16895915
    30. hNopp140 serves as a negative regulator of CK2 and InsP(6) stimulates the activity of CK2 by blocking the interaction between hNopp140 and CK2 PMID: 17038328
    31. a stabilized form of CK2beta can be used to inhibit cell proliferation PMID: 17681943
    32. protein kinase CK2 is involved in cell cycle regulation and indicate the mechanism by which CDC25A turnover might be regulated by Chk1 in the absence of DNA damage. PMID: 17912454
    33. Further studies in transgenic mice and cultured cells suggest that cellular toxicity, including proteasomal dysfunction, increases casein kinase 2 activity, which results in elevated Ser129 alpha-syn phosphorylation. PMID: 18451726
    34. The regulatory beta-subunit of protein kinase CK2 regulates cell-cycle progression. PMID: 18469858
    35. These findings support the view that CK2beta regulates various intracellular processes by modulating the activity of protein kinases that are distinct from CK2. PMID: 18560763
    36. Data show that these CK2-targeted motifs in MDC1 are required to mediate NBS1 association with chromatin-flanking sites of unrepaired DNA double-strand breaks. PMID: 18583988
    37. In epithelial cells, a fraction of CK2 is associated to the plasma membrane and that this localization is controlled by cell-matrix interactions. PMID: 18587631
    38. presents unbound three-dimensional structure of a CK2beta construct that is fully capable of CK2alpha recruitment and quantify its affinity to CK2alpha thermodynamically PMID: 18824508
    39. CK2beta is widely expressed in endometrial carcinoma , and suggest a role in cell proliferation and anchorage-independent cell growth PMID: 19056846
    40. Casein kinase 2 phosphorylates human cytomegalovirus pUL84, and this interaction is required for oriLyt-dependent DNA replication. PMID: 19091862
    41. These studies support CK2beta as an important regulator of ALK-1 signaling and ALK-1-mediated functions in endothelial cells. PMID: 19592636
    42. These experiments indicate that casein kinase II phosphorylation of varicella-zoster virus open reading frame 63 S186 occurs in the nucleus and possibly identify an initial molecular event operative in virus reactivation. PMID: 19759161

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  • 蛋白家族：
    Casein kinase 2 subunit beta family
  • 数据库链接：

    HGNC: 2460

    OMIM: 115441

    KEGG: hsa:1460

    STRING: 9606.ENSP00000365025

    UniGene: Hs.73527