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  4. CST6 Antibody

CST6 Antibody

  • 货号：
    CSB-PA827150
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA827150(CST6 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA827150(CST6 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q15828
  • 基因名：
    CST6
  • 别名：
    CST 6 antibody; CST6 antibody; Cystatin 6 antibody; Cystatin E antibody; Cystatin E/M antibody; Cystatin M antibody; Cystatin M/E antibody; Cystatin-6 antibody; Cystatin-E antibody; Cystatin-M antibody; Cystatin6 antibody; CystatinE antibody; CystatinM antibody; Cysteine proteinase inhibitor antibody; CYTM_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human CST6
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    High affinity inhibitor for cathepsin L, cathepsin L2 (cathepsin V), and legumain. Involved in the regulation of epidermal cornification, and hair follicle morphogenesis and maintenance.
  • 基因功能参考文献：
    1. High CST6 expression is associated with lymph-node metastasis in Triple-Negative Breast Cancer. PMID: 29530995
    2. Results provide evidence that cystatin E/M is a tumor suppressor gene which plays an important role in the regulation of NF-kappaB. PMID: 27090639
    3. Low CST6 expression is associated with breast cancer. PMID: 24742492
    4. Developed a Methylation-Sensitive High Resolution Melting Analysis (MS-HRMA) assay for the investigation of CST6 promoter methylation in breast cancer patients.CST6 promoter was methylated in 39/80 of FFPEs. PMID: 23088560
    5. The CST6 promoter is highly methylated in circulating cell-free DNA of breast cancer patients, but not in healthy individuals. PMID: 23006792
    6. Data show a regulatory role of cystatin E/M in controlling both intra- and extracellular legumain activity. PMID: 22902879
    7. The ectopic expression of CST6 in cancer cells rescued mice from overt osteolytic metastasis and deaths in the animal study, while CST6 knockdown markedly enhanced cancer cell bone metastasis and shortened animal survival. PMID: 22688893
    8. An association between the quantity of CST6 methylation and the expression statuses of estrogen receptor, progesterone receptor, and HER4 in tumor tissues was found PMID: 21092257
    9. the level of cystatin E/M regulates legumain activity and hence the invasive potential of human melanoma cells PMID: 20074384
    10. CST6 is not a major gene contributing to type 1 and 2 harlequin ichthyosis PMID: 12839564
    11. Cystatin M suppresses the malignant phenotype of MDA-MB-435S cells. PMID: 14676833
    12. Complete loss of expression of cystatin M was observed in two of three stage IV breast cancer patients. Immunohistochemical studies confirmed that expression of cystatin M in IDCs was partially or completely lost. PMID: 15466187
    13. This study thus provides the first evidence that CST6 plays a role in the modulation of genes, particularly, genes that are highly relevant to breast cancer progression. PMID: 16356477
    14. Identification of CTSV & CTSL as targets for cystatin M/E, their (co)-expression in the stratum granulosum of skin, and activity of CTSL toward transglutaminase 3 strongly imply an important role for them in the differentiation process of human epidermis. PMID: 16565075
    15. Tumors displaying CST6 gene methylation, display methylation in both ductal carcinoma in situ and invasive breast carcinoma lesions and reduced expression of cystatin M in these tumors was confirmed by immunohistochemistry PMID: 16912163
    16. strong link between CST6 promoter hypermethylation and loss of CST6 expression in breast cancer cell lines PMID: 17043665
    17. Cystatin M may encode a novel epigenetically inactivated candidate tumor suppressor gene. PMID: 17099723
    18. Methylation-dependent epigenetic silencing of CST6 represents an important mechanism for loss of CST6 during breast tumorigenesis and/or progression to metastasis. PMID: 17540367
    19. cystatin E/M is a cervical cancer suppressor gene and that the gene is inactivated by somatic mutations and promoter hypermethylation. PMID: 18506750
    20. results demonstrate that epigenetic silencing of CST6 is frequent in adult and pediatric brain tumors and occurs in TICs, which are thought to give rise to the tumor PMID: 18607344
    21. CST6, CXCL14, DHRS3, and SPP1 are regulated by BRAF signaling and may play a role in papillary thyroid carcinoma pathogenesis PMID: 18676742
    22. These findings imply that CST6 is likely to involve in the proliferation and survival of pancreatic cancer probably through its proteinase inhibitory activity, and it is a promising molecular target for development of new therapeutic strategies for PDAC PMID: 18754876
    23. The cysteine protease inhibitor cystatin M/E is a key regulator of a biochemical pathway that leads to epidermal terminal differentiation. PMID: 19005484
    24. Cystatin M (CST6) tumor suppressor gene is concurrently down-regulated with other loci in breast epithelial cells cocultured with cancer-associated fibroblasts. PMID: 19074894
    25. cystatin M/E has a role in skin barrier formation and a potential role as a tumor suppressor gene [review] PMID: 19262604
    26. Results suggest that the downregulation of the CST6 gene is associated with promoter histone modifications and that this association plays an important role in prostate cancer progression during the invasive and metastatic stages of the disease. PMID: 19503093
    27. Methylation of cystatin M promoter is associated with breast cancer. PMID: 19551853

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Cystatin family
  • 组织特异性：
    Restricted to the stratum granulosum of normal skin, the stratum granulosum/spinosum of psoriatic skin, and the secretory coils of eccrine sweat glands. Low expression levels are found in the nasal cavity.
  • 数据库链接：

    HGNC: 2478

    OMIM: 601891

    KEGG: hsa:1474

    STRING: 9606.ENSP00000311313

    UniGene: Hs.139389