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CTAGE5 Antibody

  • 货号：
    CSB-PA006131LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA006131LA01HU diluted at 1:600 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CTAGE5 Polyclonal antibody
  • Uniprot No.：
    O15320
  • 基因名：
    CTAGE5
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Endoplasmic reticulum export factor CTAGE5 protein (515-632AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CTAGE5 Antibody (CSB-PA006131LA01HU)，的标记方式是Non-conjugated。对于CTAGE5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA006131LB01HU CTAGE5 Antibody, HRP conjugated ELISA
    FITC CSB-PA006131LC01HU CTAGE5 Antibody, FITC conjugated
    Biotin CSB-PA006131LD01HU CTAGE5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. TANGO1/CTAGE5 receptor serves as a polyvalent template for assembly of large COPII coats. PMID: 27551091
    2. In this study, we identified specific and critical residues in the Sec12-binding region of cTAGE5 (E75A K76A, K89A, and S97A) and confirmed that cTAGE5-mediated Sec12 accumulation at ER exit sites is required for collagen VII secretion. PMID: 27170179
    3. Data indicate that MIA2 represents a potential novel acute phase protein and MIA2 expression responds to liver damage in chronic liver diseases. PMID: 12586826
    4. The novel gene MIA2 acts as a tumour suppressor in hepatocellular carcinoma. PMID: 17881540
    5. population and bioinformatic analysis of MGEA6 P521A variation as a risk factor for Fahr's disease; genetic screen data show this mutation is very rare; bioinformatics analysis provided conflicting findings PMID: 20838928
    6. cTAGE5 forms a complex with TANGO1 (MIA3), a previously characterized cargo receptor for collagen VII PMID: 21525241
    7. HBx activates hepatoma cell growth and proliferation through repression of the potential tumor suppressor MIA2. PMID: 22120627
    8. 22 members of an Iranian family with basal ganglia calfication as well as 100 controls were genotyped for the C>G P521A variant of CTAGE5, but none were found. PMID: 23054591
    9. Findings suggest that the roles of MIA2 might be based on the variety of the integrins and the subtypes of mitogen-activated protein kinase in oral carcinoma. PMID: 23511560
    10. Sec12 recruitment to endoplasmic reticulum exit sites is organized by its direct interaction with cTAGE5, a previously characterized collagen cargo receptor component, which functions together with TANGO1 at endoplasmic reticulum exit sites. PMID: 25202031
    11. These findings define an interaction between the common MIA2(I141M) variant and the ER stress/UPR system and specify a subgroup of PDAC patients who are more likely to benefit from adjuvant chemotherapy. PMID: 25657029

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  • 相关疾病：
    Autoantibodies against CTAGE5 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL).
  • 蛋白家族：
    CTAGE family
  • 数据库链接：

    HGNC: 7057

    OMIM: 602132

    STRING: 9606.ENSP00000280083

    UniGene: Hs.287694