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CTDSP2 Antibody

  • 货号：
    CSB-PA006143GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O14595
  • 基因名：
    CTDSP2
  • 别名：
    Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 2 antibody; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 antibody; conserved gene amplified in osteosarcoma 4 antibody; conserved gene amplified in osteosarcoma antibody; CTDS2_HUMAN antibody; Ctdsp2 antibody; NIF2 antibody; NLI interacting factor 2 antibody; NLI-interacting factor 2 antibody; Nuclear LIM interactor interacting factor 2 antibody; Nuclear LIM interactor-interacting factor 2 antibody; OS4 antibody; Protein OS 4 antibody; Protein OS-4 antibody; PSR2 antibody; SCP2 antibody; Small C-terminal domain phosphatase 2 antibody; Small CTD phosphatase 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CTDSP2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
  • 基因功能参考文献：
    1. CTDSP2 induces p21(Cip1/Waf1) through increasing the activity of Ras. PMID: 25990325
    2. These results suggest that SCP2 is involved in promoter clearance during steroid-activated transcription. PMID: 16724108
    3. SCP2 acts as a phosphatase for regulatory phosphorylations in the linker region of Smad1 and Smad2 PMID: 17085434
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver.
  • 数据库链接：

    HGNC: 17077

    OMIM: 608711

    KEGG: hsa:10106

    STRING: 9606.ENSP00000381148

    UniGene: Hs.524530