CTNNBIP1 Antibody

1. Data demonstrated that ICAT was highly expressed in cervical cancer tissues and had a role in control of epithelial-mesenchymal transition (EMT) in cervical cancer cells. Its overexpression promoted cell proliferation, migration, invasion and resulted in EMT by disrupting the stability of E-cadherin/betacatenin complex. PMID: 29048651
2. Low PLD1 expression and high ICAT expression were significantly associated with increased survival in colorectal cancer patients. PMID: 28939743
3. The present work aims to investigate the relationship between the expression of AEG-1(astrocyte elevated gene-1), b-FGF(basic-fibroblast growth factor), beta-catenin, Ki-67, TNF-alpha (tumor necrosis factor-alfa) other prognostic parameters in DC (Ductal Carcinomas) and ductal intraepithelial neoplasm. We found a relationship between these factors. PMID: 26096243
4. Overexpression of ICAT promoted Caski cells' proliferation, arrested the cell cycle in the S phase and enhanced cell migration. Conclusion Overexpression of ICAT can promote the proliferation and migration of Caski cervical cancer cells. PMID: 27774943
5. Somatic mutation of beta-catenin (CTNNB1) is known to be crucial for Wilms tumor development in up to 15% of cases. PMID: 27679509
6. CTNNBIP1 expression correlated with longer overall survival in LAC patients. This study reveals that miR-214 plays a critical role in CSLC self-renewal and stemness by targeting CTNNBIP1. PMID: 26299367
7. Data show that microRNA miR-215 activates beta-catenin pathways by decreasing catenin beta interacting protein 1 (CTNNBIP1)expression in gliomas. PMID: 26317904
8. Simultaneous silencing of beta-catenin and STAT3 synergistically induces apoptosis and inhibits cell proliferation in HepG2 liver cancer cells. PMID: 25845340
9. Finally, pro-incubation with idebenone inhibited mitochondrial dysfunction induced by oxLDL through the mitochondrial-dependent apoptotic pathway and GSK3beta/beta-catenin signalling pathways. PMID: 26284974
10. A potent beta-catenin inhibitor, ICAT/CTNNBIP1 was a direct target of miR-424-5p. PMID: 25175916
11. Particulate matter (PM10) downregulates E-Cadherin/beta-Catenin expression. PMID: 26047787
12. A statistically significant lapatinib- and gefitinib-induced repression of cyclin D1, MMP9 and beta-catenin in CERV196 cells. PMID: 26124325
13. Nuclear YAP and cytoplasmic beta-catenin play important roles in carcinogenesis. PMID: 26124339
14. review of control of cell fate and proliferation in colon cancer PMID: 25193262
15. miR-603 regulates glioma development via Wnt-beta-cateninn signaling pathway and its WIF1 and CTNNBIP1 targets. PMID: 25681036
16. These results indicate that beta-catenin translation is initiated via the IRES and this is regulated by PTX, suggesting that regulation of the IRES-dependent translation of beta-catenin may be involved in the cancer cell response to PTX treatment. PMID: 25849888
17. ICAT may serve as a tumor-suppressor in human glioma. PMID: 25434796
18. Suppressing TrpC5 expression decreased nuclear beta-catenin accumulation, reduced the induction of ABCB1, and reversed 5-fluorouracil neoplastic resistance. PMID: 25404731
19. Our results indicate that HDAC1 plays an important role in chondrogenesis and may represent a therapeutic target for modulation of cartilage development. PMID: 25445594
20. ASPP2 prevents beta-catenin from transactivating ZEB1 directly by forming an ASPP2-beta-catenin-E-cadherin ternary complex PMID: 25344754
21. It involved in the control of cell growth, differentiation, and apoptosis. PMID: 24390805
22. PTHrP was found to inhibit DKK1 expression through c-Jun-mediated inhibition of beta-catenin activity on the DKK1 promoter. PMID: 23752183
23. beta-catenin inhibitor ICAT modulates the invasive motility of melanoma cells. PMID: 24514042
24. Neither cyclin D1 nor beta-catenin was expressed in a statistically significant manner, concluding that the development of MCCs is independent of beta-catenin and cyclin D1 expression and these proteins are not suitable as prognostic markers. PMID: 23928935
25. beta-catenin is delocalized and survivin is over-expressed in recurrent sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumor PMID: 23572266
26. Thus, our results indicated abnormal expression of CD44V6, CDH11, and beta-catenin in osteosarcomas and osteochondromas, which may provide important indicators for further research. PMID: 23971040
27. The data show that Snail1 and beta-catenin, besides association with loss of hormone dependence, protect cancer cells from hypoxia and may serve as an important target in the treatment of breast cancer. PMID: 23973669
28. This study demonistrated that mean protein and mRNA levels of beta-catenin were significantly decreased in both the PFC and hippocampus of teenage suicide group compared to controls. PMID: 23110823
29. beta-catenin accumulation in the nucleus regulates expression of Nanog protein and has a role in progression of non-small cell lung cancer PMID: 23648139
30. These findings suggest that Sphingosine-1-phosphate activates signaling leading to nuclear translocation of beta-catenin in osteoblast-like cells and upregulation of osteoptotegerin and osteoblast differentiation markers PMID: 23612487
31. beta-catenin was significantly associated with nodal stage, TNM stage, and E-cadherin expression. beta-catenin could be early marker for identification of occult metastases in oral SCC. PMID: 22525043
32. In this review, we will discuss the points of intersection between the Wnt/beta-catenin and Hippo/YAP pathways and how these interactions contribute to homeostasis, organ repair, and tumorigenesis. PMID: 23027379
33. ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression. PMID: 23339455
34. our data clearly identify protein stabilizing mutations of the beta-catenin gene as a common feature of nested stromal epithelial tumors of the liver, similarly as in hepatoblastomas. PMID: 22749188
35. Microatellite-stable cases exhibited reduced membranous beta catenin and increased cytoplasmic and nuclear beta catenin compared with microsatellite-instable cases. PMID: 21791486
36. Airway basal cell beta-catenin determines cell fate and its mis-expression is associated with the development of human lung cancer. PMID: 22081448
37. Cholangiocarcinoma cell lines express E-cad and beta-cat but with different localizat- ion patterns. PMID: 22075503
38. Inhibitor of beta-catenin and T-cell factor (ICAT), a beta-catenin binding protein that inhibits the canonical Wnt/beta-catenin signaling pathway, in AR signaling, was investigated. PMID: 21885566
39. Reduced/aberrant beta-catenin expression was seen in benign and malignant salivary gland tumors. PMID: 20034989
40. ICAT is a direct transcriptional target of E2F1, and activation of ICAT by E2F1 is required for E2F1 to inhibit beta-catenin activity. PMID: 21532622
41. overexpression of beta-catenin may be an important contributing factor to glioma progression. PMID: 20300972
42. High beta-catenin is associated with glioma progression. PMID: 21636708
43. LMP1 may be involved in nasopharyngeal carcinogenesis via beta-catenin signaling pathway PMID: 21336584
44. A coactivator role of CARM1 in the dysregulation of beta-catenin activity in colorectal cancer cell growth and gene expression PMID: 21478268
45. When both E-cadherin and beta -catenin expressions were reduced, there was a significant unfavourable prognosis. PMID: 21574102
46. The protein expression levels of Wnt1, beta-catenin and Cyclin D1 were all positively correlated with the Karnofsky performance scale (KPS) score and World Health Organization (WHO) grades of patients with gliomas. PMID: 20809334
47. beta-catenin is expressed in actinic chelitis and squamous cell carcinoma of the lip PMID: 20970365
48. Data show that elevated beta-catenin expression level may be an adverse indicator for the prognosis of ESCC patients at stage T2-3N0M0, especially for those with T3 lesions or stage IIB diseases. PMID: 21049553
49. cytoplasmic accumulation of beta-catenin can induce Tcf/Lef-mediated transcriptional activity, up-regulate MMP-7, and induce epithelial and mesenchymal transition (EMT). PMID: 20878057
50. our results support the concept that STAT3 upregulates the protein expression and transcriptional activity of beta-catenin in breast cancer. PMID: 20830236

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HGNC: 16913

OMIM: 607758

KEGG: hsa:56998

STRING: 9606.ENSP00000366466

UniGene: Hs.463759