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CTNNBL1 Antibody

  • 货号：
    CSB-PA777238
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA777238(CTNNBL1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA777238(CTNNBL1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q8WYA6
  • 基因名：
    CTNNBL1
  • 别名：
    5730471K09Rik antibody; Beta catenin like 1 antibody; Beta catenin like protein 1 antibody; Beta-catenin-like protein 1 antibody; C20orf33 antibody; Cadherin associated protein antibody; Catenin beta like 1 antibody; Chromosome 20 open reading frame 3 antibody; CTBL1_HUMAN antibody; CTNN protein antibody; CTNNBL 1 antibody; Ctnnbl1 antibody; dJ633O20.1 antibody; FLJ21108 antibody; NAP antibody; Nuclear associated protein antibody; nuclear protein NAP antibody; Nuclear-associated protein antibody; NYD SP19 antibody; OTTMUSP00000016933 antibody; P14 antibody; P14L antibody; PP8304 antibody; RP5 1118M15.1 antibody; Testis development protein NYD SP19 antibody; Testis development protein NYD-SP19 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human CTNNBL1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.
  • 基因功能参考文献：
    1. CTNNBL1 regulates multiple splicing events and gene expression in ovarian cancer cells PMID: 28501461
    2. Tthis study identified WNT5B and CTNNBL1 for peak bone mineral density and body composition in males from the Han Chinese ethnic group. PMID: 26733379
    3. The results show that CTNNBL1 enhances the association of CWC15 and CDC5L, both core Prp19 complex proteins and identify an overlap in the region of CDC5L that binds either CTNNBL1 or CWC15 suggesting the two proteins might exchange places in the complex. PMID: 26130721
    4. Variants in the gene CTNNBL1 (encoding catenin-beta-like 1, located on chromosome 20 q11.23-q12) have been found to be associated with verbal episodic memory performance. PMID: 25268258
    5. The crystal structure of CTNNBL1 shows that the protein coalphansists mainly of alpha-helices and forms an armadillo (ARM) repeat. structure PMID: 24598747
    6. Results indicate CTNNBL1 as a unique selective nuclear localization signals (NLSs)-binding protein with striking differences from karyopherin-alphas. PMID: 24269683
    7. CTNNBL1 crystal structure provides critical insights into the molecular interactions between CTNNBL1 and its protein partners. PMID: 23897482
    8. From this gene expression data and fMRI experiments suggests a role for the beta-catenin-like protein 1 in human episodic memory. PMID: 22105620
    9. There are abnormal expression of beta-catenin and activation of Wnt signaling pathway in human esophageal carcinoma cell line Eca-109. PMID: 21215100
    10. There was a significantly positive correlation between LMP1 expression and abnormal expression of beta-catenin in nasopharyngeal carcinoma tissue. PMID: 21055033
    11. CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31 PMID: 21385873
    12. Study suggests a novel mechanism for the development of obesity, where CTNNBL1 may play an important role. PMID: 18325910
    13. The results, therefore, identify residues in AID involved in its in vivo targeting and suggest they might act through interaction with CTNNBL1, giving possible insight into the linkage between AID recruitment and target-gene transcription. PMID: 18722174
    14. We detected no confirmation of the recent association of variants in CTNNBL1 with obesity in a population of Central European ancestry PMID: 19228371
    15. CTNNBL1 variants associated with body weight and height, and confer the risk of developing obesity PMID: 19245693

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  • 亚细胞定位：
    [Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.
  • 组织特异性：
    Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid.
  • 数据库链接：

    HGNC: 15879

    OMIM: 611537

    KEGG: hsa:56259

    STRING: 9606.ENSP00000355050

    UniGene: Hs.472667