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  4. CTR9 Antibody

CTR9 Antibody

  • 货号：
    CSB-PA006178GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6PD62
  • 基因名：
    CTR9
  • 别名：
    Ctr 9 antibody; CTR9 antibody; Ctr9 Paf1/RNA polymerase II complex component; homolog antibody; CTR9; Paf1/RNA polymerase II complex componen antibody; CTR9; S. cerevisiae; homolog of antibody; CTR9_HUMAN antibody; KIAA0155 antibody; p150 antibody; p150(TSP) antibody; p150TSP. antibody; Paf1/RNA polymerase II complex component homolog Ctr9 antibody; RNA polymerase associated protein CTR9 homolog antibody; RNA polymerase-associated protein CTR9 homolog antibody; SH2 binding phosphoprotein antibody; SH2 domain binding protein 1 (tetratricopeptide repeat containing) antibody; SH2 domain binding protein 1 antibody; SH2 domain-binding protein 1 antibody; SH2-binding phosphoprotein of 150 kDa antibody; SH2BP1 antibody; Tetratricopeptide repeat-containing antibody; Tetratricopeptide-containing SH2-binding phosphoprotein 150-KD antibody; TPR containing; SH2-binding phosphoprotein of 150 kDa antibody; TSBP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CTR9
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is invol...显示更多
  • 基因功能参考文献：
    1. A novel CTR9 germline variant, located in a consensus splice acceptor site, was found to segregate with Wilms tumor in the family. PMID: 29292210
    2. Our data demonstrated that Ctr9, independent of other PAFc subunits, controls ERalpha-target gene expression by regulating global chromatin occupancies of ERalpha and RNAPII. PMID: 27829357
    3. Ctr9, a key subunit of hPAFc, is a central regulator of estrogen signaling that drives ERalpha(+) breast tumorigenesis PMID: 26494790
    4. Ctr9, formerly identified as a nuclei protein, interacts with the dopamine transporter in the cytoplasmic compartment. PMID: 26048990
    5. CTR9 is a PAF1 complex gene whose germline mutations predispose to Wilms tumour PMID: 25099282
    6. CTR9, a component of PAF complex, controls elongation block at the c-Fos locus via signal-dependent regulation of chromatin-bound NELF dissociation. PMID: 23593388
    7. MLL interacts directly with the polymerase associated factor complex (PAFc) via Paf1 and CTR9. PAFc augments MLL and MLL-AF9 mediated transcriptional activation of Hoxa9 and their interaction is essential for leukemogenesis. PMID: 20541477
    8. CTR9 participates in the transcription of IL-6-responsive genes through the regulation of DNA association of STAT3 and modification of histone methylation PMID: 17911113

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  • 亚细胞定位：
    Nucleus speckle.
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 16850

    OMIM: 609366

    KEGG: hsa:9646

    STRING: 9606.ENSP00000355013

    UniGene: Hs.725151