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CWC22 Antibody

  • 货号：
    CSB-PA875721LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA875721LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA875721LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CWC22 Polyclonal antibody
  • Uniprot No.：
    Q9HCG8
  • 基因名：
    CWC22
  • 别名：
    CWC22 antibody; CWC22 spliceosome associated protein homolog (S. cerevisiae) antibody; CWC22 spliceosome associated protein homolog antibody; CWC22_HUMAN antibody; EIF4GL antibody; fSAPb antibody; Functional spliceosome associated protein b antibody; KIAA1604 antibody; NCM antibody; Nucampholin homolog antibody; Pre-mRNA-splicing factor CWC22 homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Pre-mRNA-splicing factor CWC22 homolog protein (360-623AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CWC22 Antibody (CSB-PA875721LA01HU)，的标记方式是Non-conjugated。对于CWC22 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA875721LB01HU CWC22 Antibody, HRP conjugated ELISA
    FITC CSB-PA875721LC01HU CWC22 Antibody, FITC conjugated
    Biotin CSB-PA875721LD01HU CWC22 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.
  • 基因功能参考文献：
    1. The binding mode of CWC22 to eIF4AIII reveals a facet of how MIF4G domains use their versatile structural frameworks to activate or inhibit DEAD-box proteins. PMID: 24218557
    2. CWC22 connects pre-mRNA splicing and exon junction complex assembly. PMID: 22959432
    3. The essential splicing factor CWC22 has acquired functions in exon junction complex assembly and nonsense-mediated decay during evolution from single-celled to complex eukaryotes. PMID: 23236153
    4. CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly PMID: 22961380
  • 亚细胞定位：
    Nucleus. Nucleus speckle.
  • 蛋白家族：
    CWC22 family
  • 数据库链接：

    HGNC: 29322

    OMIM: 615186

    KEGG: hsa:57703

    STRING: 9606.ENSP00000387006

    UniGene: Hs.311363