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CYFIP2 Antibody

  • 货号：
    CSB-PA951951
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HEPG2 Hela cells using CYFIP2 Polyclonal Antibody diluted at 1:500. Secondary antibody was diluted at 1:20000
    • Immunohistochemical analysis of paraffin-embedded human-tonsil, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-tonsil, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:200
  • 其他：

产品详情

  • Uniprot No.：
    Q96F07
  • 基因名：
  • 别名：
    CYFIP2 antibody; KIAA1168 antibody; PIR121Cytoplasmic FMR1-interacting protein 2 antibody; p53-inducible protein 121 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from CYFIP2 at AA range: 1171-1220
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-2000
    ELISA 1:10000-20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
  • 基因功能参考文献：
    1. Study characterized the functional roles of the two brain-specific phosphorylation sites (S582 and T1067) of CYFIP2 in cultured hippocampal neurons; found that overexpression of the phospho-blocking T1067A mutant significantly decreased the density of stubby spines, but not other types of spines. Study found that T1067 phosphorylation of CYFIP2 could potentially weaken the interaction between CYFIP2 and Nap1. PMID: 28692454
    2. Increased expression of the cytoplasmic FMR1-interacting protein 2 (CYFIP2), a known FMRP interactor, is detected in fragile X syndrome. PMID: 22268788
    3. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. PMID: 17245118
  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome.
  • 蛋白家族：
    CYFIP family
  • 组织特异性：
    Expressed in T-cells. Increased expression is observed in CD4(+) T-lymphocytes from patients with multiple sclerosis (at protein level).
  • 数据库链接：

    HGNC: 13760

    OMIM: 606323

    KEGG: hsa:26999

    STRING: 9606.ENSP00000325817

    UniGene: Hs.519702