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CYP26C1 Antibody

  • 货号：
    CSB-PA009422
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q6V0L0
  • 基因名：
    CYP26C1
  • 别名：
    CP26C_HUMAN antibody; cyp26b1l antibody; CYP26C1 antibody; cyp26d1 antibody; Cytochrome P450 26C1 antibody; Cytochrome P450 family 26 subfamily C polypeptide 1 antibody; Cytochrome P450; subfamily XXVIC polypeptide 1 antibody; EG546726 antibody; FFDD4 antibody; FLJ45301 antibody; MGC158120 antibody; retinoic acid catabolizing enzyme antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human CYP26C1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate).
  • 基因功能参考文献：
    1. Together, these findings describe CYP26C1 as the first genetic modifier for SHOX deficiency. PMID: 27861128
    2. Elevated expression of CYP26C1 in primary breast carcinomas PMID: 26009309
    3. Focal facial dermal dysplasia, type IV results from the loss of function mutations in CYP26C1. PMID: 23161670
    4. CYP26A1 and CYP26C1 play a pivotal role in the pathogenesis of nonsyndromic bilateral and unilateral optic nerve aplasia. PMID: 21850183
    5. may play a specific role in catabolizing both all-trans and 9-cis isomers of retinoic acid. PMID: 14532297
    6. Observational study of gene-disease association. (HuGE Navigator) PMID: 16385451
    7. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 19703508
    8. Observational study of gene-disease association. (HuGE Navigator) PMID: 16933217

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  • 相关疾病：
    Focal facial dermal dysplasia 4 (FFDD4)
  • 亚细胞定位：
    Membrane; Single-pass membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 组织特异性：
    Detected in most tissues at very low level.
  • 数据库链接：

    HGNC: 20577

    OMIM: 608428

    KEGG: hsa:340665

    STRING: 9606.ENSP00000285949

    UniGene: Hs.369993