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CYP2U1 Antibody

  • 货号：
    CSB-PA001970
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of LOVO cells using CYP2U1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q7Z449
  • 基因名：
    CYP2U1
  • 别名：
    CYP2U1; Cytochrome P450 2U1; Long-chain fatty acid omega-monooxygenase
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CYP2U1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May downregulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin.
  • 基因功能参考文献：
    1. Most CYP2U1 missense mutations in hereditary spastic paraplegia 56 lead to an inhibition of enzymatic activity that can be explained by the loss of proper heme binding to the protein or modification in protein structure. PMID: 29034544
    2. we report a patient with SPG56 with novel compound heterozygous mutations in CYP2U1 which were identified by whole exome sequencing. Our patient exhibited complex features together with delayed myelination, broadening the phenotypic spectrum of SPG56, and implying that CYP2U1 should be screened in HSP with delayed myelination PMID: 28725025
    3. the mode of interaction of several Fe(III)-heme ligands and substrates with the active site of CYP2U1 on the basis of spectroscopic and molecular docking data.[CYP2U1] PMID: 27456766
    4. protein sequence of CYP2U1 displayed two unique characteristics when compared to those of the human CYPs, the presence of a longer N-terminal region upstream of the putative trans-membrane helix (TMH) containing 8 proline residues, and of an insert of about 20 amino acids containing 5 arginine residues between helices A' and A PMID: 28743672
    5. Cytochrome P450 2U1 (CYP2U1) exhibits several distinctive characteristics among the 57 human CYPs, such as its presence in almost all living organisms with a highly conserved sequence, its particular gene organization with only five exons, its major location in thymus and brain, and its protein sequence involving an unusually long N-terminal region containing 8 proline residues. [review] PMID: 28083596
    6. This is the first formal report of pigmentary degenerative maculopathy associated with a CYP2U1 homozygous mutation PMID: 26914923
    7. we identified two novel mutations in CYP2U1 in two unrelated Hereditary spastic paraplegia patients by whole exome sequencing PMID: 27292318
    8. This is the first report of CYP2E1 and CYP2U1 protein expression in human Amygdala. PMID: 25872594
    9. Data suggest that the 3D model could be useful to identify other substrates of cytochrome P450 2U1 (CYP2U1) and help in understanding its physiologic roles. PMID: 25857771
    10. The CYP2U1 gene shows a low mutation frequency in a general population of complicated hereditary spastic paraparesis PMID: 24337409
    11. human cytochrome P450 2U1 oxidizes endogenous N-arachidonoylserotonin PMID: 24563460
    12. CYP1B1 and CYP2U1 were the only quantifiable CYPs in in freshly isolated human brain microvessels. PMID: 21707071
    13. Genetic polymorphism of CYP2U1, a cytochrome P450 involved in fatty acids hydroxylation. PMID: 20630735
    14. CYP2U1 plays an important physiological role in fatty acid signaling processes in both cerebellum and thymus PMID: 14660610

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  • 相关疾病：
    Spastic paraplegia 56, autosomal recessive (SPG56)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 组织特异性：
    Widely expressed with stronger expression in thymus, heart and cerebellum.
  • 数据库链接：

    HGNC: 20582

    OMIM: 610670

    KEGG: hsa:113612

    STRING: 9606.ENSP00000333212

    UniGene: Hs.109087