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CYP4B1 Antibody

  • 货号：
    CSB-PA007584
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO cells using CYP4B1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P13584
  • 基因名：
    CYP4B1
  • 别名：
    CP4B1_HUMAN antibody; CYP4B1 antibody; CYPIVB1 antibody; Cytochrome P450 4B1 antibody; Cytochrome P450 family 4 subfamily B polypeptide 1 antibody; Cytochrome P450 subfamily IVB polypeptide 1 antibody; Cytochrome P450-HP antibody; Microsomal monooxygenase antibody; P450HP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CYP4B1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
  • 基因功能参考文献：
    1. the Ser207 insertion does not rescue the P450 functional activity of human CYP4B1 that has been lost during evolution. PMID: 26355749
    2. A proline residue in the meander region at position 427 in human CYP4B1 and 422 in rabbit CYP4B1 is important for protein stability and rescues the 4-ipomeanol bioactivation. PMID: 25247810
    3. polymorphism in humans: evidence for a non-functional allelic variant PMID: 12142726
    4. CYP4B1 is a senescene-associated gene in normal human oral keratinocytes. PMID: 12837283
    5. Results demostrated an increased risk of bladder cancer associated with the CYP4B1*1/*2 and *2/*2 genotypes. PMID: 18713828

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 组织特异性：
    Detected in the liver and lung (at protein level).
  • 数据库链接：

    HGNC: 2644

    OMIM: 124075

    KEGG: hsa:1580

    STRING: 9606.ENSP00000360991

    UniGene: Hs.436317