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CYTH3 Antibody

  • 货号：
    CSB-PA002833
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COS7 cells using GRP1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O43739
  • 基因名：
  • 别名：
    CYTH3 antibody; ARF nucleotide-binding site opener 3 antibody; ARNO3 antibody; ARNO3 protein antibody; CYH3_HUMAN antibody; Cyth3 antibody; Cytohesin-3 antibody; General receptor of phosphoinositides 1 antibody; Grp1 antibody; PH antibody; PH, SEC7 and coiled-coil domain-containing protein 3 antibody; Protein ARNO3 antibody; PSCD3 antibody; SEC7 and coiled-coil domain-containing protein 3 antibody; SEC7 homolog C antibody; Sec7-3 antibody; Sec7c antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat,Monkey
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human GRP1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization.
  • 基因功能参考文献：
    1. Cytohesin-3 was upregulated in hepatocellular carcinoma tissues, correlating with overall survival/relapse-free survival and tumor size/vascular invasion. PMID: 24966920
    2. The PH domains of cytohesin 2/ARNO and cytohesin 3/GRP1 are responsible for the differential effects of these proteins on cell adhesion to fibronectin. PMID: 22454518
    3. incorporation of the E345K charge reversal mutation into the GRP1 PH domain enhances PI(4,5)P(2) affinity 8-fold and yields constitutive plasma membrane targeting in cells PMID: 21932773
    4. GRP1 is a new corepressor for thyroid hormone receptors, which modulates both positive and negative regulation by T3 by decreasing TR-complex formation on thyroid response elements PMID: 15878955
  • 亚细胞定位：
    Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell junction, tight junction.
  • 组织特异性：
    Almost absent from liver, thymus and peripheral blood lymphocytes.
  • 数据库链接：

    HGNC: 9504

    OMIM: 605081

    KEGG: hsa:9265

    STRING: 9606.ENSP00000297044

    UniGene: Hs.487479