Cleaved-ACAN (D369) Antibody

1. Reciprocal translocation t(10;15)(q22.3;q26.1) interrupting ACAN gene is associated with short stature. PMID: 29302920
2. genetic association studies in pediatric population in Japan: Data suggest that mutations in ACAN (aggrecan), FGFR3 (fibroblast growth factor receptor-3), or GHRHR (growth- hormone-releasing-hormone receptor) are associated with idiopathic short stature in the population studied. PMID: 28768959
3. In bicuspid aortic valve disease, there was a significant reduction of aggrecan expression in bicuspid aortic valve. PMID: 28986054
4. Overexpression of miR-3150a-3p decreased ACAN expression in nucleus pulposus cells, whereas inhibition of miR-3150a-3p increased ACAN expression. In addition, ACAN expression was negatively correlated with intervertebral disc degeneration (IDD) grade. The reduction of ACAN expression induced by the upregulation of miR-3150a-3p might participate in the development of IDD. PMID: 29554650
5. Our study demonstrated that altered levels of ADAMTS-1 and aggrecan may have a partial role in the etiopathogenesis of Polycystic ovary syndrome (PCOS), and ADAMTS-1 could be a predictive marker for implantation success in PCOS patients. PMID: 28417352
6. ACAN mutation is a relative common cause of familial severe short stature PMID: 28396070
7. Chondrogenic potential was higher and Wnt/beta-catenin signaling was more potently activated by a GSK-3beta inhibitor in the posterior than in the anterior part of the human infant sclera. PMID: 27336854
8. single nucleotide variants of ACAN and their haplotypes are associated with the severity of lumbar disc herniation. PMID: 28742099
9. Four of 29 small for gestational age children with advanced bone age had an ACAN gene mutation (13.8%). Mutations were related to additional characteristics: midface hypoplasia, joint problems, and broad great toes. PMID: 27710243
10. SNVs of candidate genes in ACAN metabolic pathway are associated with severity of Lumbar disc degeneration and Modic changes in patients with chronic mechanical low back pain. PMID: 28081267
11. Heterozygous aggrecan mutations result in a phenotypic spectrum ranging from mild and proportionate short stature to a mild skeletal dysplasia with disproportionate short stature and brachydactyly. PMID: 27870580
12. deacetylation promotes SOX9 nuclear translocation and hence its ability to activate ACAN. PMID: 26910618
13. Femoral and tibial cartilage show a different behaviour concerning expression values for the genes Col1A1, Col2A1 and Agg. PMID: 28302318
14. The genotype and allele frequencies of the COL2A1 genetic polymorphisms (rs1793953 and rs2276454) and the Aggrecan VNTR polymorphisms differed significantly between the case group and the control group.the genotype and allele frequencies of the COL2A1 genes, rs1793953 and rs2276454, and Aggrecan VNTR significantly differed in terms of Pfirrmann grades III, IV, and V PMID: 27991836
15. Decrease in mRNA expression of ACAN is associated with Osteoarthritis. PMID: 27428952
16. Results showed an association between short alleles and lumbar disc herniation (LDH), corroborating the hypothesis that aggrecan with shorter repeat lengths can lead to a reduction in the physiological proteoglycan function of intervertebral disc hydration and, consequently, increased individual susceptibility to LDH. PMID: 28002585
17. Citrullinated Proteoglycan Aggrecan is a new member of citrullinated proteins identified in human joints. PMID: 26943656
18. Idiopathic short stature is due to novel heterozygous mutation of the aggrecan gene. PMID: 25741789
19. Identification of homozygous deletion in ACAN and other candidate variants in familial classical Hodgkin lymphoma by exome sequencing. PMID: 25715982
20. ACAN positive perineuronal nets and glial cells were decreased in the amygdala of szhizophrenia and bipolar disorder patients compared to controls. PMID: 25603412
21. An underlying interaction between aggrecan VNTR and obesity in symptomatic lumbar disc herniation. PMID: 25188217
22. The results suggest that regions within ACAN is associated with ACL injury susceptibility and that genetic sequence variability within genes encoding proteoglycans may potentially modulate the ligament fibril properties. PMID: 24552666
23. results suggested that genetic variants in ACAN and MET are associated with HM. Functional roles of ACAN and MET in the development of HM need to be further investigated PMID: 24766640
24. Data show there was no significant difference in the aggrecan (ACAN) rs1516797 genotype or allele distributions between the carpal tunnel syndrome (CTS) and control groups. PMID: 25173489
25. Heterozygous mutations in ACAN can cause a mild skeletal dysplasia, which presents clinically as short stature with advanced bone age. PMID: 24762113
26. ROCKi decreased the association between ETS-1 and its binding sites on the MMP-3 promoter, whereas ROCKi promoted the interaction between SOX9 and the AGN promoter. PMID: 24111521
27. SHOX2, like SHOX, regulates NPPB directly whilst activates ACAN via its cooperation with the SOX trio. PMID: 24421874
28. microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 and ACAN. PMID: 24063364
29. significant increased risks were found among Asians with shorter alleles of Aggrecan PMID: 24296484
30. PKCepsilon activation in late passage NP cells may represent a molecular basis for aggrecan availability, as part of an PKCepsilon/ERK/CREB/AP-1-dependent transcriptional program that includes upregulation of both chondrogenic genes and microRNAs PMID: 24312401
31. The expression of growth differentiation factor 5 (GDF5) and aggrecan in 15 cases of salivary gland pleomorphic adenomas, was investigated. PMID: 24398992
32. Data indicate link protein peptide (LPP) upregulates expression of aggrecan and collagen II at both mRNA and protein levels. PMID: 23370687
33. the subsequent presentation of aggregan from ECM leads to CD4(+) T-cell activation and effector cell formation. PMID: 24032649
34. ADAMTS-4_v1 is expressed as a protein in vivo in human osteoarthritis synovium, functions as an aggrecanase, and cleaves other proteoglycan substrates. PMID: 23897278
35. The total mole fraction of unelongated xylose residues per aggrecan was significantly less (p = 0.03) after IL-1beta treatment compared to control cultures. PMID: 23237500
36. aggrecan alleles with shorter VNTR length have a role in intervertebral disc degeneration, while VDR (TaqI, FokI, ApaI) gene polymorphisms do not [meta-analysis] PMID: 23209686
37. The concentration of aggrecan, biglycan, and decorin was determined in six regions of the human supraspinatus tendon. PMID: 22329809
38. The reduction in keratan sulfate levels and the strong correlation between chondroitin 6-sulfate and keratan sulfate levels indi-cates suppressed cartilage turnover after arthroscopic surgery. PMID: 22441960
39. Identification of enhancer sequences involved in the regulation of expression of the human ACAN gene. PMID: 22820679
40. Data suggest that matrix metalloproteinases are mainly involved in normal aggrecan turnover in extracellular matrix and may have less-active roles in aggrecan degradation during knee injury or osteoarthritis (where aggrecanase-1 has central role). PMID: 22670872
41. In the CNS, aggrecan is expressed in a precise and tightly regulated manner both temporally and spatially. (Review) PMID: 22297263
42. Increased expression of collagen II, aggrecan, and cartilage oligomeric matrix protein (COMP), were observed during differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes. PMID: 22241609
43. Yiqi Huayu Bushen Recipe increased the expression of aggrecan, decreased the expression of type X collagen, and promoted cell proliferation in cells from degenerated human intervertebral discs. PMID: 22015197
44. In Turkish population, short repeated alleles of the aggrecan gene are associated with increased disc degeneration and disc herniation. PMID: 21948754
45. Data show that a molecular complex of fibronectin and aggrecan predicts response to lumbar ESI for radiculopathic back pain with HNP. PMID: 21224775
46. in the human cerebral cortex, discrete, layer-specific PNNs are assembled through the participation of selected aggrecan isoforms that characterize defined subsets of cortical neurons PMID: 19220578
47. The objective of the present study was to assess the immunolocalization of aggrecan in the annulus, and to assess molecular gene expression patterns in the annulus extracellular matrix. PMID: 21689646
48. Carrying a copy of the aggrecan allele with 21 repeats may increase the risk of multiple disc degeneration in subjects less than 40 years of age. PMID: 20936487
49. This study tests the hypothesis that disease severity is characterized by alterations in expression of cartilage-specific genes for aggrecan and collagen type II. PMID: 21655647
50. Confocal immunostaining demonstrated colocalization of m-calpain and the aggrecan product within the lower hypertrophic chondrocytes and in limited region of the pericellular matrix. PMID: 21117903

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HGNC: 319

OMIM: 155760

KEGG: hsa:176

UniGene: Hs.2159