Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. Cxcl11 Antibody

Cxcl11 Antibody

  • 货号：
    CSB-PA09289A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA09289A0Rb at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    The rabbit IgG polyclonal antibody was raised against the recombinant C-X-C motif chemokine 11 protein (22-98aa) expressed in mouse. The rabbit anti-serum collected antibody was affinity purified using Protein G, resulting in a purity of over 95%.

    This rabbit anti-mouse Cxcl11 polyclonal antibody is capable of recognizing the mouse Cxcl11 protein and has been validated for use in ELISA and IHC. It can be utilized to detect the presence, quantify the level, or visualize the distribution of Cxcl11 protein in experimental settings.

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Cxcl11 Polyclonal antibody
  • Uniprot No.：
    Q9JHH5
  • 基因名：
  • 别名：
    Cxcl11 antibody; Scyb11C-X-C motif chemokine 11 antibody; Interferon-inducible T-cell alpha chemoattractant antibody; I-TAC antibody; Small-inducible cytokine B11 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse
  • 免疫原：
    Recombinant Mouse C-X-C motif chemokine 11 protein (22-98AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Cxcl11 Antibody (CSB-PA09289A0Rb)，的标记方式是Non-conjugated。对于Cxcl11 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA09289B0Rb Cxcl11 Antibody, HRP conjugated ELISA
    FITC CSB-PA09289C0Rb Cxcl11 Antibody, FITC conjugated
    Biotin CSB-PA09289D0Rb Cxcl11 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
  • 基因功能参考文献：
    1. although the expression of CXCL9 and CXCL11 are increased after spinal nerve ligation, they may not contribute to the maintenance of neuropathic pain. PMID: 29712506
    2. These findings functionally integrate K17, hnRNP K, and gene expression along with RSK and CXCR3 signaling in a keratinocyte-autonomous axis and provide a potential basis for their implication in tumorigenesis PMID: 25713416
    3. very low doses of CXCL11 rapidly suppress signs of EAE in C57BL/6 mice lacking functional CXCL11. PMID: 24713654
    4. Data indicate that epidermis-derived I-TAC (Cxcl11) triggers a sustained Th2-response that determines the outcome of a complex immunological process. PMID: 24398292
    5. Analysis of genes within the Listr1 locus identified a frameshift mutation in the Cxcl11 gene of the C57BL/6 strain that prevents production of the mature chemokine CXCL11. PMID: 24566892
    6. Cxcl10 and cxcl11 are new hair-specific transcriptional targets of ectodysplasin, and they indicates involvement of chemokines in hair development. PMID: 22277947
    7. the CXCL11-heparin interaction has two different affinities for glycosaminoglycans PMID: 20363748
    8. I-TAC can have an important role during virus infections and vaccinia virus has evolved ways to avoid inducing I-TAC expression. PMID: 15030574
    9. I-TAC acts as an antagonist for CCR5. I-TAC inhibited the binding of macrophage-inflammatory protein-1alpha (MIP-1alpha)/CC chemokine ligand 3 (CCL3) to cells transfected with CCR5 and to monocytes. PMID: 15178708
    10. Acute ethanol intoxication impairs lung expression of Cxcl11, interfering with pulmonary response to bacterial challenge. PMID: 17889309
    11. homologous to human T cell attracting chemokine CXC receptor ligand 11; involved in calcium mobilization and chemotaxis PMID: 11500837

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine alpha (chemokine CxC) family
  • 数据库链接：

    KEGG: mmu:56066

    UniGene: Mm.131723