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DARS Antibody

  • 货号：
    CSB-PA006505LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DARS Polyclonal antibody
  • Uniprot No.：
    P14868
  • 基因名：
    DARS
  • 别名：
    Aspartate tRNA ligase 1 cytoplasmic antibody; Aspartate tRNA ligase antibody; Aspartate--tRNA ligase antibody; Aspartyl tRNA synthetase antibody; Aspartyl tRNA synthetase cytoplasmic antibody; Aspartyl-tRNA synthetase antibody; AspRS antibody; Cell proliferation inducing gene 40 protein antibody; Cell proliferation inducing protein 40 antibody; Cell proliferation-inducing gene 40 protein antibody; cytoplasmic antibody; Dars antibody; DKFZp781B11202 antibody; MGC111579 antibody; SYDC_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Aspartate--tRNA ligase, cytoplasmic protein (1-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DARS Antibody (CSB-PA006505LA01HU)，的标记方式是Non-conjugated。对于DARS Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA006505LB01HU DARS Antibody, HRP conjugated ELISA
    FITC CSB-PA006505LC01HU DARS Antibody, FITC conjugated
    Biotin CSB-PA006505LD01HU DARS Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
  • 基因功能参考文献：
    1. Genetic variants of the DARS gene may influence individual susceptibility to isolated VSD in Chinese Han population. Risk of VSD was significantly associated with rs2164331 [G/A; odds ratio (OR) = 0.78, 95% confidence interval (CI) = 0.69-0.91; P = 3.17 x 10(-3)], rs6738266 [G/A; OR = 1.17, 95% CI = 1.05-1.29, P = 1.83 x 10(-3)], and rs309143 [G/A; OR = 1.09, 95% CI = 1.01-1.17; P = 3.12 x 10(-2)]. PMID: 27871331
    2. Report on the crystal structure of human cytosolic aspartyl-tRNA synthetase (DRS) at a resolution of 2.25 A. PMID: 23609930
    3. Mutations in DARS cause hypomyelination with brain stem and spinal cord involvement and leg spasticity. PMID: 23643384
    4. the N-terminus shows a less-ordered structure with flexible beta-turn, suggesting that when tRNA is stretched, the dissociation rate of Asp-tRNA from aspartyl-tRNA synthetase is reduced, giving time for elongation factor 1alpha to interact with Asp-tRNA. PMID: 12824064
  • 相关疾病：
    Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL)
  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Class-II aminoacyl-tRNA synthetase family, Type 2 subfamily
  • 组织特异性：
    Expression in the developing and adult brain shows similar patterns. Highly expressed in the ventricular and subventricular zones, including hippocampal subfields, the midlateral temporal cortex and the frontal polar cortex. The cerebellum, cerebral corte
  • 数据库链接：

    HGNC: 2678

    OMIM: 603084

    KEGG: hsa:1615

    STRING: 9606.ENSP00000264161

    UniGene: Hs.503787