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DCAF7 Antibody

  • 货号：
    CSB-PA026056GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P61962
  • 基因名：
  • 别名：
    AN11 antibody; Dcaf7 antibody; DCAF7_HUMAN antibody; DDB1- and CUL4-associated factor 7 antibody; HAN11 antibody; Human anthocyanin antibody; Petunia antibody; Seven WD repeat protein of the AN11 family 1 antibody; SWAN 1 antibody; WD repeat domain 68 antibody; WD repeat protein An11 homolog antibody; WD repeat-containing protein 68 antibody; WD repeat-containing protein An11 homolog antibody; WDR68 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human WDR68
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
  • 基因功能参考文献：
    1. Immunoprecipitation and pulldown experiments identified DCAF7 as an adaptor for the association of the adenovirus E1A protein with DYRK1A and HIPK2 PMID: 27307198
    2. knockdown of DCAF7 reduced the degradation of DNA ligase I in response to inhibition of proliferation and replacement of ubiquitylated lysine residues reduced the in vitro ubiquitylation of DNA ligase I by Cul4-DDB1 and DCAF7. In contrast, a different E3 ubiquitin ligase regulates FEN-1 turnover. PMID: 27573245
    3. results demonstrate that the molecular chaperone TRiC/CCT is essential for correct protein folding, DYRK1A binding, and nuclear accumulation of WDR68. PMID: 25342745
    4. DYRK1A binds specifically to WDR68 in cells; the binding, but not the phosphorylation event, induces the nuclear translocation of WDR68. PMID: 21777625
    5. Han11 was required to allow coupling of MEKK1 to DYRK1 and HIPK2. PMID: 20940704
    6. that AN11 may be a physiological regulator of GLI1 transcriptional activity PMID: 16887337

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm.
  • 蛋白家族：
    WD repeat DCAF7 family
  • 数据库链接：

    HGNC: 30915

    OMIM: 605973

    KEGG: hsa:10238

    STRING: 9606.ENSP00000308344

    UniGene: Hs.410596