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DCP2 Antibody

  • 货号：
    CSB-PA810265ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: m7GpppN-mRNA hydrolase antibody at 7μg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: Jurkat whole cell lysate
      Lane 3: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 49, 45 kDa
      Observed band size: 49 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA810265ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA810265ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DCP2 Polyclonal antibody
  • Uniprot No.：
    Q8IU60
  • 基因名：
    DCP2
  • 别名：
    DCP2 antibody; DCP2 decapping enzyme homolog (S. cerevisiae) antibody; DCP2, S. cerevisiae, homolog of antibody; DCP2_HUMAN antibody; decapping enzyme 2, S. cerevisiae, homolog of antibody; decapping enzyme homolog (S. cerevisiae) antibody; FLJ33245 antibody; hDpc antibody; m7GpppN-mRNA hydrolase antibody; mRNA decapping enzyme 2 antibody; mRNA-decapping enzyme 2 antibody; Nucleoside diphosphate-linked moiety X motif 20 antibody; nudix (nucleoside diphosphate linked moiety X)-type motif 20 antibody; Nudix motif 20 antibody; NUDT20 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human m7GpppN-mRNA hydrolase protein (1-240AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
  • 基因功能参考文献：
    1. Human Dcp2 levels and activity are controlled by a competition between decapping complex assembly and Dcp2 degradation. PMID: 25870104
    2. Data show that Y14 interacts directly with the decapping factor Dcp2 and the 5' cap structure of mRNAs via different but overlapping domains. PMID: 23115303
    3. an mRNA decapping enzyme demonstrated to contain intrinsic decapping activity PMID: 12218187
    4. Human Dcp2 is a catalytically active mRNA decapping enzyme that localizes to the cytoplasm PMID: 12486012
    5. hDcp2 can specifically bind to and can regulate the stability of a subset of mRNAs PMID: 18039849
    6. These data support the novel notion of the association between Ro52 with hDCP2 protein in cytoplasmic p-bodies, playing a role in mRNA metabolism in response to cellular stimulation. PMID: 18361920

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  • 亚细胞定位：
    Cytoplasm, P-body. Nucleus.
  • 蛋白家族：
    Nudix hydrolase family, DCP2 subfamily
  • 组织特异性：
    Expressed in brain and testis. Not detected in heart (at protein level).
  • 数据库链接：

    HGNC: 24452

    OMIM: 609844

    KEGG: hsa:167227

    STRING: 9606.ENSP00000373715

    UniGene: Hs.443875