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DDO Antibody

  • 货号：
    CSB-PA006593LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA006593LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA006593LA01HU at dilution of 1:100
    • Western Blot
      Positive WB detected in: Rat liver tissue
      All lanes: DDO antibody at 3.5μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 38, 31, 41, 34 kDa
      Observed band size: 38 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DDO Polyclonal antibody
  • Uniprot No.：
    Q99489
  • 基因名：
    DDO
  • 别名：
    D aspartate oxidase antibody; D-aspartate oxidase antibody; DASOX antibody; DDO 1 antibody; DDO 2 antibody; DDO antibody; FLJ45203 antibody; OTTHUMP00000017000 antibody; OXDD_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human D-aspartate oxidase protein (37-161AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DDO Antibody (CSB-PA006593LA01HU)，的标记方式是Non-conjugated。对于DDO Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA006593LB01HU DDO Antibody, HRP conjugated ELISA
    FITC CSB-PA006593LC01HU DDO Antibody, FITC conjugated
    Biotin CSB-PA006593LD01HU DDO Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate.
  • 基因功能参考文献：
    1. This study is the first to report robust age associations for DNA methylation in MYOF and DDO, both of which have plausible functional roles in aging PMID: 28255110
    2. SNPSs R216Q and S308N reduce enzyme activity towards acidic d-amino acids, decrease the binding affinity for the coenzyme flavin adenine dinucleotide and decrease the temperature stability. Expression of DDO genes carrying the R216Q or S308N SNP substitutions may increase the d-aspartate content in humans and alter homeostasis of several other amino acids. PMID: 28629864
    3. Characterization of the enzymatic and structural properties of human D-aspartate oxidase and comparison with those of the rat and mouse enzymes PMID: 25747990
    4. There is a significant increase in DDO mRNA expression in the prefrontal cortex of patients with schizophrenia compared to controls. PMID: 25689573
    5. data do not suggest that DDO plays a role in the etiology of schizophrenia in the German population PMID: 19125110

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  • 亚细胞定位：
    Peroxisome.
  • 蛋白家族：
    DAMOX/DASOX family
  • 数据库链接：

    HGNC: 2727

    OMIM: 124450

    KEGG: hsa:8528

    STRING: 9606.ENSP00000357920

    UniGene: Hs.591348