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DDX19B Antibody

  • 货号：
    CSB-PA781970
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from HT-29 cells, using DDX19B antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DDX19B Polyclonal antibody
  • Uniprot No.：
    Q9UMR2
  • 基因名：
    DDX19B
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human DDX19B.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.
  • 基因功能参考文献：
    1. These results imply that DBP5, GLE1 and IP6 have a conserved and individual function in the cytoplasmic mRNA expression. Variations in phenotype are due to the difference in each function of DBP5, GLE1 and IPPK in intracellular mRNA metabolism. PMID: 29746542
    2. DDX19 interacts with pre-termination complexes (preTCs) in a nucleotide-dependent manner. Furthermore, DDX19 increases the efficiency of termination complex (TC) formation and the peptide release in the presence of eukaryotic release factors. DDX19 also stabilizes ribosome complexes with translation elongation factors eEF1 and eEF2. PMID: 28180304
    3. Ddx19 is an RNA export factor required for nuclear import of the SRF coactivator MKL1 PMID: 25585691
    4. Dbp5, Gle1-IP6 and Nup159: a working model for mRNP export. PMID: 22064466
    5. identification and characterization of a gene coding a novel isoform PMID: 12219940
    6. Using in vitro assays, the s demonstrate that NUP214 decreases both the RNA binding and ATPase activities of DBP5. PMID: 19219046
    7. Results describe the crystal structures of human DDX19, a DEXD/H-box protein, in its open and closed cleft conformations. PMID: 19244245

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  • 亚细胞定位：
    Cytoplasm. Nucleus, nucleoplasm.
  • 蛋白家族：
    DEAD box helicase family, DDX19/DBP5 subfamily
  • 数据库链接：

    HGNC: 2742

    OMIM: 605812

    KEGG: hsa:11269

    STRING: 9606.ENSP00000288071

    UniGene: Hs.221761