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DDX3Y Antibody

  • 货号：
    CSB-PA070114
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O15523
  • 基因名：
    DDX3Y
  • 别名：
    ATP dependent RNA helicase DDX3Y antibody; ATP-dependent RNA helicase DDX3Y antibody; DBY antibody; DDX3Y antibody; DDX3Y_HUMAN antibody; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 Y linked antibody; DEAD box protein 3 Y chromosomal antibody; DEAD box protein 3 antibody; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide Y chromosome antibody; Y-chromosomal antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human DDX3Y.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway.
  • 基因功能参考文献：
    1. DDX3Y gene rescue of a Y chromosome AZFa deletion restores germ cell formation and transcriptional programs. PMID: 26456624
    2. results suggest that MSY genes may play an important role in neural differentiation and demonstrate that DDX3Y could play a multifunctional role in neural cell development PMID: 26144214
    3. fetal germ cell DDX3Y protein expression suggests a role in early spermatogonial proliferation PMID: 22466863
    4. We show here the development of a coordinated B and T-cell response to DBY in a recipient of sex mismatched allogeneic hematopoietic stem-cell transplantation. PMID: 21709606
    5. Gene structure of the human DDX3 and chromosome mapping of its related sequences.Its organization was the same as that of the human DBY gene, a closely related sequence present on the Y chromosome. PMID: 11710523
    6. graft-versus-host (GVH) disease after HLA-identical stem cell transplantation is the result of recognition of minor histocompatibility antigens (mHags) by immunocompetent T lymphocytes from recipient origin. PMID: 11929796
    7. coordinated B and T cell immune response to H-Y minor histocompatibility antigen, DBY, after allogeneic transplant PMID: 15096539
    8. Human Y- and X-encoded DEAD box RNA helicase proteins DDX3Y and DDX3X are interchangeable and have an essential function. Ddx3x mRNA was expressed in almost every cell in mouse testis, suggesting that Ddx3x is involved in spermatogenesis PMID: 15383328
    9. The finding that the testicular transcript of DDX3Y is significantly decreased in patients with severe spermatogenenic failure, especially in those presenting maturation arrest, suggests an important role of DDX3Y during spermatogenesis. PMID: 17881721
    10. Expression of DDX3Y is detected in all myeloid and lymphoid leukemic cells that carry an intact Y chromosome. PMID: 18299450

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  • 相关疾病：
    DDX3Y is located in the 'azoospermia factor a' (AZFa) region on chromosome Y which is deleted in Sertoli cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading to azoospermia.
  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner.
  • 蛋白家族：
    DEAD box helicase family, DDX3/DED1 subfamily
  • 组织特异性：
    Widely expressed at the mRNA level, with highest levels in testis. Testis-specific (at protein level). Expressed predominantly in spermatogonia, but occasionally detected in some pre-leptotene/leptotene spermatocytes.
  • 数据库链接：

    HGNC: 2699

    OMIM: 400010

    KEGG: hsa:8653

    STRING: 9606.ENSP00000336725

    UniGene: Hs.99120