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DEDD Antibody

  • 货号：
    CSB-PA006648ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA006648ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006648ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DEDD Polyclonal antibody
  • Uniprot No.：
    O75618
  • 基因名：
    DEDD
  • 别名：
    CASP8IP1 antibody; Death effector domain containing antibody; Death effector domain containing protein antibody; Death effector domain containing testicular molecule antibody; Death effector domain-containing protein antibody; Death effector domain-containing testicular molecule antibody; DEDD 1 antibody; dedD antibody; DEDD_HUMAN antibody; DEDD1 antibody; DEDPro 1 antibody; DEDPro1 antibody; DEFT antibody; FLDED 1 antibody; FLDED-1 antibody; FLDED1 antibody; KE 05 antibody; KE05 antibody; OTTHUMP00000031822 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Death effector domain-containing protein (1-318AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro.
  • 基因功能参考文献：
    1. LINC00472 contributed to the increase in lung adenocarcinoma cell apoptosis and the inhibition of proliferation via regulating miR-24-3p/ DEDD. PMID: 30175664
    2. DEDD protein role in cell proliferation and migration of bladder cancer PMID: 28000900
    3. Via direct interaction with the class III PI-3-kinase (PI3KC3)/Beclin1, DEDD activated autophagy and induced the degradation of Snail and Twist, two master regulators of EMT PMID: 22719072
    4. FAS-associated death domain (FADD)-DED-induced reactive oxygen species (ROS) generation is triggered by membrane localization of FADD-DED, which shifts the cells into a state that stimulates and fuels ROS and ultimately results in cell death. PMID: 20070122
    5. DEDD forms nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC PMID: 11965497
    6. DEDD and DEDD2 may be important mediators for death receptors and that they may target caspases to the nucleus. PMID: 12527898

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  • 亚细胞定位：
    Cytoplasm. Nucleus, nucleolus.
  • 组织特异性：
    Widely expressed with highest levels in testis.
  • 数据库链接：

    HGNC: 2755

    OMIM: 606841

    KEGG: hsa:9191

    STRING: 9606.ENSP00000356985

    UniGene: Hs.744092