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DEFA4 Antibody

  • 货号：
    CSB-PA007746
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P12838
  • 基因名：
    DEFA4
  • 别名：
    DEFA4 antibody; DEF4Neutrophil defensin 4 antibody; Defensin antibody; alpha 4 antibody; HNP-4 antibody; HP-4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Defensin α4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production.
  • 基因功能参考文献：
    1. DEFA4 displays antimicrobial activity against E. coli, S. faecalis, and C. albicans. PMID: 2500436
    2. DEFA1-3 and DEFA4 mRNA level in peripheral blood cells can be used to identify chronic myeloid leukaemia patients who are at risk of being imatinib-resistant, before initiation of the therapy. PMID: 21734341
    3. The combination of an increased expression of the antimicrobial peptide DEFA-4, the oncogene S100-A7, epidermal growth factor, and tenascin-c, and a decreased Doc-1 expression in oral leukoplakia might characterize its potency of malignant transformation. PMID: 20727496
    4. Crystal structure of HNP-4. PMID: 17088326
    5. DEFA4 was upregulated in IPF patients with acute exacerbation PMID: 19363140

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Alpha-defensin family
  • 数据库链接：

    HGNC: 2763

    OMIM: 601157

    KEGG: hsa:1669

    STRING: 9606.ENSP00000297435

    UniGene: Hs.591391