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DEFA6 Antibody

  • 货号：
    CSB-PA980801GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q01524
  • 基因名：
    DEFA6
  • 别名：
    alpha 6 antibody; DEF6 antibody; DEF6_HUMAN antibody; DEFA 6 antibody; DEFA6 antibody; Defensin 6 antibody; Defensin alpha 6 antibody; Defensin alpha 6 Paneth cell specific antibody; Defensin antibody; Defensin-6 antibody; HD 6 antibody; HD6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human DEFA6
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.
  • 基因功能参考文献：
    1. HD6 assembled into nanonets can prevent key steps in C. albicans pathogenesis PMID: 28198610
    2. alpha-Defensin 6 Self-Assembly Prevents Adhesion and Suppresses Virulence Traits of Candida albicans PMID: 28026958
    3. Downregulation of HD6 in noninflamed mucosa may contribute to mucosal barrier dysfunction of patients with Crohn's Disease. PMID: 26891258
    4. Paneth cell alpha-defensin 6 is an antimicrobial peptide. PMID: 25354318
    5. Native HD-6 readily self-assembles into elongated fibrils observable by transmission electron microscopy, agglutinates both Gram-negative and -positive bacteria, and prevents the Listeria monocytogenes from invading cultured cells. PMID: 25158166
    6. In the meta-analysis, DEFA6 rs13275170 and DEFB1 rs2738169 had both a 1.3-fold increased odds ratio for gastric cancer. PMID: 23028900
    7. study reports that HD6 affords protection against invasion by enteric bacterial pathogens in vitro and in vivo; after stochastic binding to bacterial surface proteins, HD6 undergoes ordered self-assembly to form fibrils and nanonets that surround and entangle bacteria PMID: 22722251
    8. Regions 2, 3 & 9, 10 were more hydrophobic than other regions. It was difficult for the HD molecule to have many conformations because of its 3 S-S bridges; however, it responds to various external factors by restricting conformation. PMID: 21873175
    9. Defensin alpha 6 (DEFA 6) may have a role in adenoma but not in progression to colon carcinoma PMID: 20979654
    10. defensin alpha6 is highly expressed in colon cancer cell lines PMID: 15613481
    11. Crystal structure of HD6. PMID: 17088326
    12. Human enteric defensin (HD)-5 and HD-6 were detected in Paneth cells, which are observed in the gastric metaplastic mucosa as well as small intestinal epithelia. PMID: 19250512

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Alpha-defensin family
  • 组织特异性：
    Paneth cells of the small intestine.
  • 数据库链接：

    HGNC: 2765

    OMIM: 600471

    KEGG: hsa:1671

    STRING: 9606.ENSP00000297436

    UniGene: Hs.711