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DEFB104A Antibody

  • 货号：
    CSB-PA840974LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA840974LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA840974LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DEFB104A Polyclonal antibody
  • Uniprot No.：
    Q8WTQ1
  • 基因名：
    DEFB104A
  • 别名：
    BD 4 antibody; BD-4 antibody; BD4 antibody; beta 104 antibody; beta 4 Defensin antibody; Beta defensin 4 antibody; Beta-defensin 104 antibody; Beta-defensin 4 antibody; D104A_HUMAN antibody; DEFB-4 antibody; DEFB104B antibody; Defensin antibody; Defensin beta 104 antibody; Defensin beta 4 precursor antibody; hBD 4 antibody; hBD-4 antibody; hBD4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Beta-defensin 104 protein (23-72AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DEFB104A Antibody (CSB-PA840974LA01HU)，的标记方式是Non-conjugated。对于DEFB104A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA840974LB01HU DEFB104A Antibody, HRP conjugated ELISA
    FITC CSB-PA840974LC01HU DEFB104A Antibody, FITC conjugated
    Biotin CSB-PA840974LD01HU DEFB104A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103.
  • 基因功能参考文献：
    1. Beta-defensin 104 displays antimicrobial activity against S. carnosus, E. coli, S. cerevisiae, and P. aeruginosa (strong). PMID: 11481241
    2. TFF3 activated the epithelial cells in culture to produce beta defensins 2 (hBD2) and beta defensins 4 PMID: 23198942
    3. Data suggest an activation of b-defensin-4 induction, in human knee meniscus by the osteoarthritis inflammatory process as a result of an endogenous antibiotic defense mechanism accompanied by an intrinsic effort of tissue remodeling. PMID: 21879330
    4. Our results suggest that copy number variation of DEFB4 may not contribute to the pathogenesis of Behcet's disease. PMID: 21385545
    5. Analysis of the DEFB4 promoter region shows remarkably high density of sequence variabilities. PMID: 20445567
    6. The variations in the genes encoding human beta-defensin-1 and -2 may be associated with the risk of severe acute pancreatitis. PMID: 20720450
    7. Data show that beta-defensin cluster (DEFB4, DEFB103 and DEFB104) varied between 2 and 9 copies per genome, and high copy numbers (>4) were underrepresented among patients, suggesting that increased copy numbers could protect from CD. PMID: 20483368
    8. We report here the application of small ubiquitin-related modifier (SUMO) fusion technology to the expression and purification of cationic antibacterial peptide hBD4. PMID: 20526896
    9. This study demonstrates, the involvement of NOD1 and DEFB4 in direct killing of Helicobacter pylori bacteria by epithelial cells and confirms the importance of NOD1 in host defence mechanisms against cagPAI(+)Helicobacter pylori infection. PMID: 20039881
    10. The mRNA level of the beta defensin 4 did not differ significantly between the two subgroups. PMID: 20128731
    11. elevated DEFB4 copy number is a risk factor for Crohn's disease PMID: 19809410
    12. There is an association of four common DEFB104 haplotypes with the risk of prostate cancer in two independent patient cohorts. PMID: 18515986

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Beta-defensin family
  • 组织特异性：
    High expression in the testis. Gastric antrum exhibited relatively high levels. A lower expression is observed in uterus and neutrophils thyroid gland, lung, and kidney. No detectable expression in other tissues tested.
  • 数据库链接：

    HGNC: 18115

    KEGG: hsa:107984148

    STRING: 9606.ENSP00000322191

    UniGene: Hs.559507