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DEFB126 Antibody

  • 货号：
    CSB-PA866323LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA866323LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DEFB126 Polyclonal antibody
  • Uniprot No.：
    Q9BYW3
  • 基因名：
    DEFB126
  • 别名：
    DEFB126 antibody; C20orf8 antibody; DEFB26Beta-defensin 126 antibody; Beta-defensin 26 antibody; DEFB-26 antibody; Defensin antibody; beta 126 antibody; Epididymal secretory protein 13.2 antibody; ESP13.2 antibody; HBD26 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Beta-defensin 126 protein (36-111AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DEFB126 Antibody (CSB-PA866323LA01HU)，的标记方式是Non-conjugated。对于DEFB126 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA866323LB01HU DEFB126 Antibody, HRP conjugated ELISA
    FITC CSB-PA866323LC01HU DEFB126 Antibody, FITC conjugated
    Biotin CSB-PA866323LD01HU DEFB126 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte. In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation.
  • 基因功能参考文献：
    1. Data indicate a significant contribution of the frame-shift polymorphism of defensin beta 126 (DEFB126) rs11467497 to male infertility. PMID: 25721098
    2. These results demonstrate that the DEFB126 core peptide has critical functions in parallel to its C-terminal tail by showing LPS-binding activity, anti-inflammatory effects and intracellular regulatory function. In addition, DEFB126 displays antimicrobial activity against E. coli, S. aureus, and C. elegans. PMID: 23229569
    3. This review shows how DEFB126 is critical for efficient transport of sperm in the female reproductive tract, preventing their recognition by the female immune system. PMID: 22710670
    4. DEFB126 genotype and lectin binding were correlated with sperm performance in the penetration assays. PMID: 21775668
    5. Analyses restricted to glioblastoma (n = 254) yielded significant associations for the SELP, DEFB126/127, SERPINI1, and LY96 genetic regions. PMID: 19423540

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  • 相关疾病：
    May be involved in infertility. Homozygosity for frameshift truncating mutations are associated with reduced sperm O-linked glycan content, impaired sperm mobility and a reduced live birth rate (PubMed:21775668, PubMed:25721098). However, for one common mutation the change in sperm sialic acid levels has been challenged (PubMed:26832966).
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Beta-defensin family
  • 组织特异性：
    High-level and epididymis-specific expression. Expression is down-regulated in infertile men.
  • 数据库链接：

    HGNC: 15900

    KEGG: hsa:81623

    STRING: 9606.ENSP00000371835

    UniGene: Hs.124211