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DEPDC1 Antibody

  • 货号：
    CSB-PA255561
  • 规格：
    ￥1100
  • 图片：
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: A172 cells, hela cells, hepg2 cells, 293T cells, Primary antibody: CSB-PA255561(DEPDC1 Antibody) at dilution 1/150, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    Q5TB30
  • 基因名：
    DEPDC1
  • 别名：
    5830484J08Rik antibody; Cell cycle control protein SDP35 antibody; DEP domain containing 1 antibody; DEP domain containing protein 1A antibody; DEP domain-containing protein 1A antibody; DEP.8 antibody; DEP1A_HUMAN antibody; DEPDC 1 antibody; DEPDC 1A antibody; DEPDC1 antibody; DEPDC1-V2 antibody; Depdc1a antibody; FLJ20354 antibody; SDP 35 antibody; SDP35 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human DEPDC1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.
  • 基因功能参考文献：
    1. Our results demonstrated that increased expression of SDP35/DEPDC1A and XPT1/DEPDC1B correlates with metastatic progression of metastatic soft tissue sarcoma PMID: 29297565
    2. The results of this study suggest that DEPDC1 represents a target molecule for the treatment of glioma. PMID: 28555424
    3. DEPDC1a, but not DEPDC1b, was required for the integrity of centrosome and organization of the bipolar spindle PMID: 28602627
    4. DEPDC1 mRNA and protein expression levels were dramatically increased in prostate cancer tissues and cell lines. Overexpression of DEPDC1 promoted, but depletion of DEPDC1 inhibited cell proliferation by regulating the G1-S phase cell cycle transition. PMID: 28634077
    5. miR-130a is an epigenetically regulated miRNA involved in regulation of key molecular and phenotypic features of prostate carcinogenesis, acting as a tumour suppressor miRNA by targeting SEC23B and DEPDC1. PMID: 27984115
    6. Results suggest that protocadherin 10 (PCDH10)-Dishevelled, EGL-10 and Pleckstrin domain containing 1 (DEPDC1)-caspase signaling may be a novel regulatory axis in endometrial endometrioid carcinoma (EEC) development. PMID: 26970279
    7. DEPDC1, plays a pivotal role in the regulation of proper mitotic progression. PMID: 25902835
    8. High DEPDC1 mRNA expression is associated with hepatocellular carcinoma/ PMID: 25605201
    9. DEPDC1 regulates vincristine-induced cell death by promoting JNK-dependent degradation of the BCL-2 family protein MCL1. PMID: 25064737
    10. Inhibition of DEPDC1A, a bad prognostic marker in multiple myeloma, delays growth and induces mature plasma cell markers in malignant plasma cells. PMID: 23646139
    11. Coimmunoprecipitation and immunocytochemistry revealed that DEPDC1 interacted and colocalized with zinc finger transcription factor ZNF224, a known transcriptional repressor. PMID: 20587513

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  • 亚细胞定位：
    Nucleus. Note=Colocalizes with ZNF224 at the nucleus.
  • 组织特异性：
    Expressed in testis. Up-regulated in bladder cancer cells (at protein level).
  • 数据库链接：

    HGNC: 22949

    OMIM: 612002

    KEGG: hsa:55635

    STRING: 9606.ENSP00000412292

    UniGene: Hs.445098