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  4. DESI2 Antibody

DESI2 Antibody

  • 货号：
    CSB-PA018584GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BSY9
  • 基因名：
    DESI2
  • 别名：
    DESI2 antibody; C1orf121 antibody; FAM152A antibody; PPPDE1 antibody; CGI-146 antibody; PNAS-4 antibody; Deubiquitinase DESI2 antibody; EC 3.4.19.12 antibody; Desumoylating isopeptidase 2 antibody; DeSI-2 antibody; PPPDE peptidase domain-containing protein 1 antibody; Protein FAM152A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PPPDE1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization.
  • 基因功能参考文献：
    1. The PPPDE1 could mediate the ubiquitin chain editing of RPS7, deubiquitinating Lys 48-linked ubiquitination, and finally stabilize RPS7 proteins. PMID: 28483520
    2. DESI2 may influence the AKT/mTOR signal in pancreatic cancer. PMID: 25079376
    3. findings suggest a novel mechanism by which elevated PNAS-4 first causes DNA-dependent protein kinase-mediated Chk1/2 activation and then results in inhibition of the Cdc25A-CDK2-cyclin E/A pathway PMID: 25918161
    4. hPNAS-4 inhibits proliferation of ovarian cancer cells by inducing S phase arrest and apoptosis via activation of Cdc25A-Cdk2-Cyclin E/Cyclin A axis and mitochondrial dysfunction-mediated caspase-dependent and -independent apoptotic pathways. PMID: 23322088
    5. PNAS-4 is not a p53 target, but overexpression of PNAS-4 is correlated to p53 inactivity in colorectal cancer. PMID: 21556770
    6. overexpression of human PNAS4 induced apoptosis and arrested cell cycle in S phase in A549 human lung adenocarcinoma cells. PMID: 19133312

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    DeSI family
  • 数据库链接：

    HGNC: 24264

    OMIM: 614638

    KEGG: hsa:51029

    STRING: 9606.ENSP00000306528

    UniGene: Hs.498317