Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. DGKB Antibody

DGKB Antibody

  • 货号：
    CSB-PA007623
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEC cells using DGK-β Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y6T7
  • 基因名：
  • 别名：
    90 kDa diacylglycerol kinase antibody; DAG kinase beta antibody; DAGK2 antibody; DGK antibody; DGK B antibody; DGK beta antibody; DGK-beta antibody; Dgkb antibody; DGKB_HUMAN antibody; Diacylglycerol kinase beta (90kD) antibody; Diacylglycerol kinase beta 90kDa antibody; Diacylglycerol kinase beta antibody; Diglyceride kinase beta antibody; KIAA0718 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human DGK-β.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol. Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation.; Does not associate with membranes but has a diacylglycerol kinase activity.
  • 基因功能参考文献：
    1. Association with the efficiency of hematopoietic stem cells (HSC) mobilization to PB were found in the SNPs of the DGKB gene involved in cell transport and SDF-1-induced migration ability and of the VCAM1 gene which is essential for HSC homing, suggesting that SNPs involved in cell migration ability might be partly involved in HSC mobilization to peripheral blood. PMID: 27839966
    2. in addition to kinase activity, plasma membrane localization via the C1 domain and basic amino acids at the C-terminus were indispensable for neurite induction by DGKbeta PMID: 24695318
    3. forced expression of diacylglycerol kinase beta abrogated DAG accumulation at the phagosome, leading to impaired respiratory burst. PMID: 23814057
    4. human diacylglycerol kinase beta gene can generate several enzyme isoforms, which can display different expression levels and subcellular localization but similar enzymatic activities in vitro. PMID: 11719522
    5. Includes the identification and expression profile of this gene (named as KIAA0718). PMID: 9872452
    6. Indicates that this protein can interact with keratin 31 and with protocadherin beta 5. PMID: 17353931

    显示更多

    收起更多

  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Cytoplasm.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    Eukaryotic diacylglycerol kinase family
  • 组织特异性：
    [Isoform 1]: Specifically expressed in brain but also detected in uterus. In adult brain, expressed in the amygdala, caudate nucleus, and hippocampus.; [Isoform 2]: More ubiquitously expressed but at lower level compared to isoform 1.
  • 数据库链接：

    HGNC: 2850

    OMIM: 604070

    KEGG: hsa:1607

    STRING: 9606.ENSP00000382260

    UniGene: Hs.567255