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DGKG Antibody

  • 货号：
    CSB-PA006836LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: DGKG antibody at 4µg/ml + Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 90, 87, 85 kDa
      Observed band size: 90 kDa
  • 其他：

产品详情

  • 产品描述：

    To produce the polyclonal antibody that targets DGKG, rabbits were immunized with the recombinant human DGKG protein (1-255aa). Afterward, this DGKG polyclonal antibody was purified using protein G affinity chromatography, resulting in a purity level exceeding 95%. It can recognize and bind to DGKG protein present in human and mouse samples.

    This DGKG polyclonal antibody has undergone rigorous validation and is appropriate for use in ELISA and WB. As such, it can be utilized to assess DGKG protein levels and detect its presence and size in different experimental contexts.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DGKG Polyclonal antibody
  • Uniprot No.：
    P49619
  • 基因名：
  • 别名：
    DGKG antibody; DAGK3Diacylglycerol kinase gamma antibody; DAG kinase gamma antibody; EC 2.7.1.107 antibody; Diglyceride kinase gamma antibody; DGK-gamma antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Diacylglycerol kinase gamma protein (1-255AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DGKG Antibody (CSB-PA006836LA01HU)，的标记方式是Non-conjugated。对于DGKG Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA006836LB01HU DGKG Antibody, HRP conjugated ELISA
    FITC CSB-PA006836LC01HU DGKG Antibody, FITC conjugated
    Biotin CSB-PA006836LD01HU DGKG Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Has no apparent specificity with regard to the acyl compositions of diacylglycerol. Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination.
  • 基因功能参考文献：
    1. Epigenetic silencing of DGKG expression is associated with skin cancer. PMID: 28218473
    2. these results indicate that DGKG is an anionic phospholipid binding protein that preferably interacts with a small highly charged head group that is very close to the glycerol or sphingosine backbone. PMID: 24486543
    3. diacylglycerol kinase gamma regulates macrophage differentiation. PMID: 12732202
    4. the interaction of diacylglycerol kinase gamma with the Src homology 2 and C1 domains of beta2-chimaerin is induced synergistically by Phorbol ester and hydrogen peroxide PMID: 17803461
  • 亚细胞定位：
    Membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Eukaryotic diacylglycerol kinase family
  • 组织特异性：
    Predominantly expressed in retina and in a much lesser extent in the brain. Other tissues contain extremely low levels of DGK-gamma.
  • 数据库链接：

    HGNC: 2853

    OMIM: 601854

    KEGG: hsa:1608

    STRING: 9606.ENSP00000265022

    UniGene: Hs.683449