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DHX58 Antibody

  • 货号：
    CSB-PA822187ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: DHX58 antibody at 12μg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: Rat kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 77 kDa
      Observed band size: 77 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA822187ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA822187ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DHX58 Polyclonal antibody
  • Uniprot No.：
    Q96C10
  • 基因名：
  • 别名：
    D11LGP2 antibody; D11lgp2e antibody; DEXH (Asp Glu X His) box polypeptide 58 antibody; DEXH box polypeptide 58 antibody; DHX 58 antibody; DHX58 antibody; DHX58_HUMAN antibody; LGP 2 antibody; LGP2 antibody; Ortholog of mouse D11lgp2 antibody; Probable ATP dependent helicase LGP2 antibody; Probable ATP dependent RNA helicase DHX58 antibody; Probable ATP-dependent helicase LGP2 antibody; Probable ATP-dependent RNA helicase DHX58 antibody; Protein D11Lgp2 homolog antibody; RIG-I-like receptor LGP2 antibody; RLR antibody; RNA helicase LGP2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Probable ATP-dependent RNA helicase DHX58 protein (389-678AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses and coronavirus SARS-CoV-2, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
  • 基因功能参考文献：
    1. Study demonstrated a tumor suppressor role of LGP2 in neuroblastoma (NB). LGP2 was effective in promoting poly (I:C)-induced NB suppression and cytoplasmic LGP2 can serve as an independent favorable prognostic factor in NB patients. PMID: 30179292
    2. genetic loss of LGP2 uncovers dsRNA-mediated RNAi albeit less strongly than complete loss of the IFN system PMID: 29351913
    3. Results indicate that pumilio RNA binding family member 1 (PUM1) is a negative regulator of RNA helicase LGP2 (LGP2), a master regulator of innate immunity genes expressed in a cascade fashion. PMID: 28760986
    4. study documents that recombinant measles virus produce defective interfering genomes that have high immunostimulatory properties via their binding to RIG-I and LGP2 proteins, both of which are cytosolic nonself RNA sensors of innate immunity. PMID: 28768856
    5. essential role in activating interferon signaling against hepatitis C virus (HCV) infection by promoting MDA5 recognition of HCV pathogen-associated molecular patterns PMID: 28090671
    6. LGP2 did not reveal significant single-SNP associations with multiple sclerosis risk. PMID: 25288302
    7. LGP2 increases the initial rate of MDA5-RNA interaction and regulates MDA5 filament assembly. PMID: 25127512
    8. results demonstrate previously unrecognized properties of LGP2 ATP hydrolysis and RNA interaction and provide a mechanistic basis for a positive regulatory role for LGP2 in antiviral signaling PMID: 23184951
    9. LGP2, a host protein induced during influenza A virus infection, downregulates the host antiviral IFN response PMID: 22837208
    10. Paramyxovirus 5 V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon beta induction. PMID: 22301134
    11. LGP2 functions as an inhibitor of the innate immune response triggered by Rabeis virus infection PMID: 21525357
    12. LGP2 competes with the kinase IKKi for a common interaction site on IPS-1, as an element of negative-feedback regulation of intracellular antiviral signaling. PMID: 17020950
    13. LGP2 can be coexpressed with RIG-I to inhibit activation of the NF-kappaB reporter expression and that LGP2 protein produced in insect cells can bind both single- and double-stranded RNA (dsRNA), with higher affinity and cooperativity for dsRNA. PMID: 18411269
    14. The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA. PMID: 19278996
    15. Cloning and expression of the mouse Lpg2 mRNA, and comparison of the ORF to that of human LPG2 mRNA. PMID: 11735219

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Helicase family, RLR subfamily
  • 组织特异性：
    Expressed in testis, nerve and spleen. Also expressed in the brain.
  • 数据库链接：

    HGNC: 29517

    OMIM: 608588

    KEGG: hsa:79132

    STRING: 9606.ENSP00000251642

    UniGene: Hs.55918