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DIAPH2 Antibody

  • 货号：
    CSB-PA006891ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: DIAPH2 antibody at 4.75μg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 126, 125 kDa
      Observed band size: 126 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006891ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA006891ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DIAPH2 Polyclonal antibody
  • Uniprot No.：
    O60879
  • 基因名：
  • 别名：
    Dia 2 antibody; DIA antibody; Dia drome antibody; Dia2 antibody; Diap 2 antibody; Diap2 antibody; DIAP2_HUMAN antibody; DIAPH 2 antibody; Diaph2 antibody; Diaphanous 2 antibody; Diaphanous homolog 2 (Drosophila) antibody; Diaphanous homolog 2 antibody; Diaphanous related formin 2 antibody; Diaphanous-related formin-2 antibody; Diaphanous2 antibody; Diaphorase 2 antibody; Diaphorase2 antibody; DRF 2 antibody; DRF2 antibody; FLJ11167 antibody; OTTHUMP00000024270 antibody; OTTHUMP00000024271 antibody; OTTHUMP00000062171 antibody; POF 2 antibody; POF antibody; POF2 antibody; Protein diaphanous homolog 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein diaphanous homolog 2 protein (1-120AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.
  • 基因功能参考文献：
    1. Low DIA2 expression is associated with breast cancer. PMID: 29596520
    2. DIAPH2 has been associated with premature ovarian insufficiency, an aging phenotype in humans. PMID: 24037343
    3. In podocytes, INF2 appears to be an important modulator of actin-dependent behaviors that are under the control of Rho/mDia signaling. PMID: 23620398
    4. Dia2 and DIP co-tether to nascent blebs and this linkage is required for bleb formation. PMID: 23024796
    5. Long HIV filopodial formation in infected dendritic cells was dependent on the formin diaphanous 2 (Diaph2) PMID: 22685410
    6. Our results indicated that DIAPH2 may be a polygenic pleiotropy for premature ovarian failure (POF) and AMD. PMID: 21386871
    7. Dia2 plays an important role in formation of lamellipodia. PMID: 18044991

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  • 相关疾病：
    Premature ovarian failure 2A (POF2A)
  • 亚细胞定位：
    [Isoform 3]: Cytoplasm, cytosol. Early endosome. Note=Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.
  • 蛋白家族：
    Formin homology family, Diaphanous subfamily
  • 组织特异性：
    Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes.
  • 数据库链接：

    HGNC: 2877

    OMIM: 300108

    KEGG: hsa:1730

    STRING: 9606.ENSP00000321348

    UniGene: Hs.226483