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DLEC1 Antibody

  • 货号：
    CSB-PA080103
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y238
  • 基因名：
    DLEC1
  • 别名：
    DLEC1 antibody; DLC1Deleted in lung and esophageal cancer protein 1 antibody; Deleted in lung cancer protein 1 antibody; DLC-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human DLEC1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential for spermatogenesis and male fertility. May play an important role in sperm head and tail formation. May act as a tumor suppressor by inhibiting cell proliferation.
  • 基因功能参考文献：
    1. We found no correlation between the DLEC1, TUSC4 and MLH1 gene expression and NSCLC patient characteristics (gender, age and smoking) or cancer histopathology. No significant differences in the gene expression among NSCLC subtypes indicate the weakness of DLEC1, TUSC4 and MLH1 expression analysis as potential differentiating markers of NSCLC subtypes in the Polish population. PMID: 28674222
    2. the expression levels of DLEC1 and ITGA9 were prominently decreased in lung tumor samples PMID: 27287342
    3. DLEC1 mediates tumor-suppressive activities through NF-kappaB signaling. PMID: 25648635
    4. DLEC1 methylation was not associated with the clinicopathological variables of gastric cancer. PMID: 25574068
    5. DLEC1 is down-regulated in head and neck squamous cell tumors and it's promoter methylation is not associated with the clinicopathological parameters. PMID: 25746324
    6. methylation-mediated silencing of DLEC1 plays an important role in multiple lymphomagenesis, and may serve as a non-invasive tumor marker for lymphoma diagnosis PMID: 23050586
    7. Repression of DLEC1 in squamous cell carcinoma tissues is associated with promoter hypermethylation. DLEC1 is downregulated in sinonasal squamous cell carcinoma and inverted papilloma and has a distinct mechanism. PMID: 22569009
    8. Epigenetic inactivation of DLEC1 was crucial in gastric and colorectal carcinogenesis. DLEC1 methylation in serum may be a promise biomarker for GAC and CRAC early diagnosis. PMID: 21443130
    9. results demonstrate that down-expression and promoter methylation of DLEC1 increased from normal tissues to premalignancies and then to malignancies. PMID: 20952247
    10. Frequent epigenetic inactivation of deleted in lung and esophageal cancer 1 gene by promoter methylation is associated with non-small-cell lung cancer. PMID: 20630829
    11. DLEC1 is often down-regulated by CpG methylation and shows tumor inhibitory function in renal cell carcinoma cells, indicating its role as a tumor suppressor PMID: 20639048
    12. DLEC1 expression levels were significantly lower in samples from patients who developed metastasis, local recurrence, or died of breast cancer when compared to those who were disease free for >10 years. PMID: 20530412
    13. DLEC1 suppresses the growth of ovarian cancer cells and its downregulation is closely associated with promoter hypermethylation and histone hypoacetylation PMID: 16756719
    14. Silencing of DLEC1 expression by promoter hypermethylation and histone deacetylation may be important in nasopharyngeal carcinoma tumorigenesis. PMID: 17099870
    15. DLEC1 is a candidate tumor suppressor gene that plays an important role in the development and progression of hepatocellular carcinoma. PMID: 18191269
    16. DLEC1 methylation was an independent marker of poor survival in patients with non-small cell lung carcinoma. PMID: 18594535
    17. DLEC1 underwent promoter methylation-associated silencing in colon and gastric tumour cell lines and primary tumours. PMID: 19156137

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  • 相关疾病：
    Lung cancer (LNCR); Esophageal cancer (ESCR)
  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Expressed in all tissues examined. Expression is highest in prostate and testis.
  • 数据库链接：

    HGNC: 2899

    OMIM: 133239

    KEGG: hsa:9940

    STRING: 9606.ENSP00000308597

    UniGene: Hs.714499