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DLG2 Antibody

  • 货号：
    CSB-PA007803
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293T-UV cells using PSD-93 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q15700
  • 基因名：
  • 别名：
    Channel associated protein of synapse 110 antibody; Channel associated protein of synapses 110kD antibody; Channel-associated protein of synapse-110 antibody; Chapsyn 110 antibody; Chapsyn-110 antibody; Chapsyn110 antibody; Discs; large homolog 2 (Drosophila) antibody; Disks large homolog 2 antibody; DKFZp781D1854 antibody; DKFZp781E0954 antibody; Dlg 2 antibody; dlg2 antibody; DLG2_HUMAN antibody; Dlgh 2 antibody; Dlgh2 antibody; FLJ37266 antibody; Gm1197 antibody; MGC131811 antibody; Postsynaptic density protein PSD 93 antibody; Postsynaptic density protein PSD-93 antibody; Postsynaptic density protein PSD93 antibody; PSD 93 antibody; PSD93 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PSD-93.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses.
  • 基因功能参考文献：
    1. DLG2 influenced the risk of Parkinson disease in Taiwan. PMID: 29290481
    2. Two novel promoters and coding first exons in the DLG2 gene were identified. These novel isoforms are expressed in the fetal brain. Deletions of these new elements were found associated with neurodevelopmental disorders. The work brings evidence for the lack of cross-annotation in human versus mouse reference genomes and nucleotide versus protein databases. PMID: 28724449
    3. DLG2 - novel candidate genes validated in a large case-control sample of schizophrenia. PMID: 26460480
    4. The PDZ1 domain of PSD-93 might accept peptides with larger residues at the C-terminus than that of PSD-95, for example the GluD2 C-terminal Ile versus the Val found at the C-terminus of NMDA receptors. PMID: 23519667
    5. This study showed that DLG2 is related the complex learning. PMID: 23201973
    6. Comparison of the structures of the binding cleft of PSD-93 PDZ1 with the previously reported structures of PSD-93 PDZ2 and PDZ3 as well as of the closely related human PSD-95 PDZ1 shows that they are very similar in terms of amino-acid composition PMID: 20054121
    7. Variation at the DLG2 locus contributes to maintenance of glucose homeostasis through regulation of insulin sensitivity and beta-cell function. PMID: 19931931
    8. Coexpression of Kir2.1 and PSD-93delta had no discernible effect upon channel kinetics but resulted in cell surface Kir2.1 clustering and suppression of channel internalization. PMID: 15304517
    9. identifies new isoform of DLG2 gene, which contains 3'-end exons of the known DLG2 gene along with the hypothetical gene FLJ37266; new isoform is specifically upregulated in renal oncocytoma PMID: 16640776
    10. postsynaptic density-93 and N-methyl-D-aspartate receptors subunits 2B mRNA are upregulated in temporal lobe tissue of epilepsy PMID: 17506987

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Membrane. Cell projection, axon. Perikaryon.
  • 蛋白家族：
    MAGUK family
  • 数据库链接：

    HGNC: 2901

    OMIM: 603583

    KEGG: hsa:1740

    STRING: 9606.ENSP00000365272

    UniGene: Hs.367656