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DLX1 Antibody

  • 货号：
    CSB-PA006952GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P56177
  • 基因名：
    DLX1
  • 别名：
    DII B antibody; Distal less homeo box 1 antibody; Distal less homeobox 1 antibody; Distal-less homeobox gene 1a antibody; Dlx 1 antibody; Dlx antibody; Dlx1 antibody; Dlx1 distal-less homeobox 1 antibody; DLX1_HUMAN antibody; Homeo box protein DLX1 antibody; Homeobox protein DLX 1 antibody; Homeobox protein DLX-1 antibody; Homeobox protein Dlx1a antibody; Homeodomain transcription factor DLX1 antibody; MGC189409 antibody; OTTHUMP00000082494 antibody; OTTHUMP00000082497 antibody; OTTMUSP00000014202 antibody; RP23-419H3.3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DLX1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions.
  • 基因功能参考文献：
    1. observations suggest that altered DLX1 methylation and expression contribute to pathogenesis of PSP by influencing MAPT. PMID: 30050033
    2. Our results provided evidence that polymorphisms in TIMP1, DLX1 and DLX2 genes may be associated with DF phenotypes. PMID: 28131910
    3. DLX1 mRNA levels were shown to be good predictors for the detection of High-grade Prostate Cancer. PMID: 27108162
    4. these data strongly suggest that DLX1 has a pivotal role in FOXM1 signaling to promote cancer aggressiveness through intensifying TGF-beta/SMAD4 signaling in high-grade serous ovarian cancer cells. PMID: 27593933
    5. TDT results showed an association between DLX1 and cleft lip and palate, in which the A allele was undertransmited (p=0.022). PMID: 25463899
    6. The study data demonstrate an association between SNP rs7888172 of the DLX1 gene and non-syndromic hypodontia in Chinese Han individuals. PMID: 22984994
    7. The regulation of fate switch between cortical and striatal interneurons is dependent on Dlx1 (and Dlx2). PMID: 23312518
    8. These findings suggest that alterations in DLX1/2 contribute to the biological consequences of FLT3 activation. PMID: 21357706
    9. DLX1 may function as a regulator of multiple signals from TGF-beta superfamily members in broad biological contexts during blood production PMID: 14671321
    10. The DLX1 and DLX2 genes lie head-to-head in 2q32; the findings support the presence of two functional polymorphisms, one in or near each of the DLX genes that increase susceptibility to, or cause, autism. PMID: 18728693

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Distal-less homeobox family
  • 组织特异性：
    Expressed in hematopoietic cell lines.
  • 数据库链接：

    HGNC: 2914

    OMIM: 600029

    KEGG: hsa:1745

    STRING: 9606.ENSP00000354478

    UniGene: Hs.407015