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DLX2 Antibody

  • 货号：
    CSB-PA006953DSR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA006953DSR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA006953DSR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DLX2 Polyclonal antibody
  • Uniprot No.：
    Q07687
  • 基因名：
    DLX2
  • 别名：
    DII A antibody; Distal less homeo box 2 antibody; Distal less homeobox 2 antibody; DLX 2 antibody; Dlx2 antibody; DLX2_HUMAN antibody; Dlx5 antibody; Homeobox protein DLX 2 antibody; Homeobox protein DLX-2 antibody; Homeobox protein DLX2 antibody; Homeobox protein TES 1 antibody; Homeobox protein TES1 antibody; Tes 1 antibody; Tes1 antibody; zgc antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Homeobox protein DLX-2 protein (1-140AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
  • 基因功能参考文献：
    1. Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis. PMID: 29242628
    2. s characterized a BMP target gene, Distal-less homeobox 2 (DLX2), and found that DLX2 promoted apoptosis and neural differentiation of glioma-initiating cells. PMID: 28459464
    3. DLX2 is a novel marker of poor prognosis and sorafenib resistance in patients with hepatocellular carcinoma. PMID: 27302463
    4. High Ki67 expression is only present in 6.8% of CaP patients and is predictive of reduced survival and increased risk of metastasis, independent of PSA, Gleason score and D'Amico risk category. DLX2 is a novel marker of increased metastasis risk found in 73% patients and 8.2% showed co-expression with a high Ki67 score PMID: 27336609
    5. High DLX-2 expression is associated with epithelial-mesenchymal transition in cancer. PMID: 26771232
    6. DLX2 plays a crucial role in radioresistance, radiation-induced epithelial to mesenchymal transition and cancer stem cell marker expression, and the expression of DLX2 is regulated by Smad2/3 signaling in A549 and MDA-MB-231 cell lines. PMID: 26799321
    7. DLX2 expression reduces the protein components of the TTI1/TTI2/TEL2 complex, a key complex required for the proper folding and stabilization of ATM and other members of the PIKK family kinase, leading to reduced ATM-p53 signaling and senescence bypass PMID: 26833729
    8. Results showed that Dlx-2 is involved in TGF-beta- and Wnt-induced epithelial-mesenchymal transition, glycolytic switch, and mitochondrial repression by Snail activation. PMID: 25651912
    9. The activation of DLX2 signaling might improve tissue regeneration mediated by MSCs of dental origin. Results provide insight into the mechanism underlying the directed differentiation of MSCs of dental origin. PMID: 24756434
    10. Increased expression of DLX2 may correlate with the advanced stage of gastric adenocarcinoma, and it may contribute to tumor development. PMID: 23674878
    11. overexpression of DLX2 indicated poor survival in the 83 glioblastoma multiforme patients PMID: 23331016
    12. Dlx2 (and Dlx1) are required to generate cortical interneurons in the medial ganglionic eminence. PMID: 23312518
    13. Dlx-2 may be involved in tumor progression via the regulation of metabolic stress-induced necrosis PMID: 21917150
    14. MDA-MB-231 breast neoplasms expressed DLX2. PMID: 21108812
    15. In corroboration with paired-like homeodomain protein 2 (PITX2) protein kinase C functional studies, a newly identified carboxyl-terminal PITX2 mutation associated with Axenfeld-Rieger syndrome demonstrates reduced phosphorylation. PMID: 15751970
    16. In mice, biological and biochemical observations suggest that functional antagonism through heterodimer formation is a mechanism for regulating the transcriptional actions of Msx and Dlx homeoproteins. PMID: 9111364
    17. results in mutated mice suggest that Dlx2 controls development of branchial arches and the forebrian, suggesting a role in craniofacil evolution PMID: 7590232
    18. provides the sequence of human DLX2 and compares it to the murine gene. PMID: 8812481
    19. In mice osteoblasts, both Dlx2 and Dlx5 are coordinately induced by BMP2 as early as 30 minutes into their growth and differentiation. PMID: 12957859

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Distal-less homeobox family
  • 数据库链接：

    HGNC: 2915

    OMIM: 126255

    KEGG: hsa:1746

    STRING: 9606.ENSP00000234198

    UniGene: Hs.419