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DMKN Antibody

  • 货号：
    CSB-PA006965GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6E0U4
  • 基因名：
    DMKN
  • 别名：
    Dermokine antibody; DMKN antibody; DMKN_HUMAN antibody; Epidermis-specific secreted protein SK30/SK89 antibody; FLJ79374 antibody; UNQ729 antibody; UNQ729/PRO1411 antibody; ZD52F10 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DMKN
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act as a soluble regulator of keratinocyte differentiation.
  • 基因功能参考文献：
    1. we showed that DMKN loss of function in Patu-8988 and PANC-1 pancreatic cancer cell lines resulted in reduced phosphorylation of STAT3.these data suggested that DMKN could be a potential prognostic biomarker and therapeutic target in pancreatic cancer. PMID: 28795470
    2. These results suggest that dermokine-beta delays early cutaneous wound healing in part by inhibiting expression of CXC chemokines containing the ERL-sequence motif. PMID: 23428944
    3. Serum DK is a potential biomarker in intraductal papillary mucinous neoplasm and invasive ductal carcinoma, when used in combination with conventional biomarkers. PMID: 23060565
    4. Dermokine-beta impairs ERK signaling through direct binding to GRP78 PMID: 22735594
    5. Dmkndelta activates Rab5 function and thus is involved in the early endosomal trafficking. PMID: 21423773
    6. Analysis of alternative spliced transcripts produced from the dermokine gene. PMID: 16374476
    7. Dermokine gene is expressed in epithelial tissues other than the skin and this expression is transcriptionally and posttranscriptionally complex. PMID: 17380110

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Dermokine family
  • 组织特异性：
    Expressed in epidermis; in the spinous and granular layers and in placenta. Also found in the epithelia of the small intestine, macrophages of the lung and endothelial cells of the lung. Isoform 15 is expressed in epidermis and placenta. Isoform 1 is expr
  • 数据库链接：

    HGNC: 25063

    KEGG: hsa:93099

    STRING: 9606.ENSP00000342012

    UniGene: Hs.417795