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DMRT1 Antibody

  • 货号：
    CSB-PA896914LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse heart tissue, Mouse lung tissue, Mouse stomach tissue
      All lanes: DMRT1 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 40, 29, 19 kDa
      Observed band size: 40 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA896914LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA896914LA01HU at dilution of 1:100
    • Western Blot
      Positive WB detected in: HL60 whole cell lysate, 293 whole cell lysate, K562 whole cell lysate
      All lanes: DMRT1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 40, 29, 19 kDa
      Observed band size: 40 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DMRT1 Polyclonal antibody
  • Uniprot No.：
    Q9Y5R6
  • 基因名：
    DMRT1
  • 别名：
    CT154 antibody; DM domain expressed in testis 1 antibody; DM domain expressed in testis protein 1 antibody; DM domain gene expressed in testis antibody; DMRT 1 antibody; dmrt1 antibody; DMRT1_HUMAN antibody; DMT 1 antibody; DMT1 antibody; Doublesex and mab 3 related transcription factor 1 antibody; Doublesex- and mab-3-related transcription factor 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Doublesex- and mab-3-related transcription factor 1 protein (195-363AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DMRT1 Antibody (CSB-PA896914LA01HU)，的标记方式是Non-conjugated。对于DMRT1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA896914LB01HU DMRT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA896914LC01HU DMRT1 Antibody, FITC conjugated
    Biotin CSB-PA896914LD01HU DMRT1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis.
  • 基因功能参考文献：
    1. DMRT1 might influence sex-specific patterns of childhood asthma, and its expression in testis tissue and lung macrophages suggests a potential involvement in hormone or immune cell regulation. PMID: 26906082
    2. The results suggest a role of changes in DMRT1 dosage in non-obstructive azoospermia potentially also through a process of gene misregulation, even though DMRT1 deleterious variants seem to be rare. PMID: 26139570
    3. The role of DMT1 in mitochondrial iron acquisition by immunofluorescence with mitochondrial markers in cells and isolated mitochondria, as well as flow cytometric quantification of DMT1-positive mitochondria from an inducible expression system. PMID: 25483589
    4. These show that DMRT proteins use a unique binding interaction, inserting two adjacent antiparallel recognition helices into a widened DNA major groove to make base-specific contacts. PMID: 26005864
    5. Point mutations of DMRT1 may be rarely associated with male infertility. PMID: 24934491
    6. The combined results indicate that DMRT1 loss-of-function mutations are a risk factor and potential genetic cause of human spermatogenic failure PMID: 23555275
    7. neither DMRT1 nor FGF9 abnormalities are frequently involved in dysgenetic male gonad development in patients with non-syndromic 46,XY disorder of sex development. PMID: 22939835
    8. Meiosis signalling is dysregulated in carcinoma in situ (CIS) cells and that a key regulator of the mitosis-meiosis switch, DMRT1, is expressed in 'early-stage' CIS cells but is down-regulated with further invasive transformation. PMID: 23303528
    9. The biological importance of the changes in expression of DMRT1 in Sertoli cells remains to be established, but it is consistent with DMRT1 reinforcing the inhibition of meiosis in the testis. PMID: 22899867
    10. Findings continue to corroborate that genes influencing male germ cell development and differentiation have emerged as the major players in inherited TGCT susceptibility. PMID: 21551455
    11. variants in or near BAK1, DMRT1, TERT-CLPTM1L, and KITLG predispose to familial and bilateral TGCT. PMID: 21617256
    12. There is evidence that DMT1 expression and function respond rapidly to changes in dietary iron content PMID: 21462105
    13. Chromosome 9p loss is the hallmark of squamous cell carcinoma, and DMRT1, DMRT3 and DOCK8 genes at 9p24.3 might be of interest for the study of the pathophysiology of SCC as potential targets for therapeutic measures. PMID: 20596660
    14. Studies identified three new susceptibility loci DMRT1, TERT and ATF7IP associated with testicular germ cell cancer. PMID: 20543847
    15. Analysis of germ cell tumors reveals gene expression changes correlated to DMRT1 levels. PMID: 20007774
    16. Comparison of genomic and mRNA sequences show that DMRT1b and c result from exonization of intronic sequences, including the exonization of an Alu element. All 99 Alu elements are non-randomly distributed among the non-coding regions on both directions. PMID: 16617334

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  • 相关疾病：
    Testicular germ cell tumor (TGCT); 46,XY sex reversal 4 (SRXY4)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    DMRT family
  • 组织特异性：
    Testis-specific. Expressed in prostate cancer (at protein level).
  • 数据库链接：

    HGNC: 2934

    OMIM: 154230

    KEGG: hsa:1761

    STRING: 9606.ENSP00000371711

    UniGene: Hs.98586