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  4. DNAJB4 Antibody

DNAJB4 Antibody

  • 货号：
    CSB-PA727123
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA727123(DNAJB4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA727123(DNAJB4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Human fetal liver tissue, mouse skeletal muscle tissue, Mouse heart tissue, Hela cells, Jurkat cells, Primary antibody: CSB-PA727123(DNAJB4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q9UDY4
  • 基因名：
    DNAJB4
  • 别名：
    DjB4 antibody; DnaJ (Hsp40) homolog subfamily B member 4 antibody; DnaJ homolog subfamily B member 4 antibody; DnaJ like heat shock protein 40 antibody; DNAJB 4 antibody; DNAJB4 antibody; DNAJW antibody; DNJB4_HUMAN antibody; Heat shock 40 kDa protein 1 homolog antibody; Heat shock protein 40 homolog antibody; HLJ 1 antibody; HLJ1 antibody; HSP40 homolog antibody; Human liver DnaJ-like protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human DNAJB4
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).
  • 基因功能参考文献：
    1. These new observations support the idea that HLJ1 is a tumor suppressor candidate and potential biomarker for breast cancer PMID: 28481734
    2. HLJ1 is an endogenous Src inhibitor that can suppress cancer metastasis through complex interacting mechanisms. PMID: 27065329
    3. HLJ1 is a strong tumor suppressor for colorectal carcinoma PMID: 24696714
    4. Low expression of DNAJB4 is associated with gastric carcinomas. PMID: 24293545
    5. Silencing of HLJ1 partially reverses the inhibition of cancer-cell invasion by andrographolide. PMID: 23306212
    6. HBV could promote HLJ1 expression by up-regulating the transcription factor YY1. PMID: 21345358
    7. acidic stress increases the association between HLJ1 and beta-actin to modulate migration of human lung cancer cells PMID: 20615403
    8. HLJ1 switches the role of NPM1, which can act as tumor suppressor or oncogene, by modulating the oligomerization of NPM1 via HLJ1-NPM1 heterodimer formation and recruiting AP-2alpha to the MMP-2 promoter. PMID: 20145123
    9. Results indicate that DjA1 and DjB4 of subfamilies A and B of human Hsp40 have different quaternary structures and chaperone functions. PMID: 15661747
    10. The increase in HLJ1 and E-cadherin expression, as well as the suppression of invasion ability, can be reversed specifically by HLJ1 siRNA. PMID: 15782117
    11. HLJ1 is a novel tumor suppressor in NSCLC, and high HLJ1 expression is associated with reduced cancer recurrence and prolonged survival of NSCLC patients. PMID: 16788156
    12. Results show that curcumin induces HLJ1, through activation of the JNK/JunD pathway, and inhibits lung cancer cell invasion and metastasis by modulating E-cadherin expression. PMID: 18794131

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  • 亚细胞定位：
    Cytoplasm. Cell membrane. Note=Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.
  • 组织特异性：
    Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver.
  • 数据库链接：

    HGNC: 14886

    OMIM: 611327

    KEGG: hsa:11080

    STRING: 9606.ENSP00000359799

    UniGene: Hs.13852