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DNAJC19 Antibody

  • 货号：
    CSB-PA007026GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96DA6
  • 基因名：
  • 别名：
    DnaJ (Hsp40) homolog; subfamily C; member 19 antibody; DnaJ homolog subfamily C member 19 antibody; DNAJC19 antibody; homolog of yeast TIM14 antibody; Mitochondrial import inner membrane translocase subunit TIM14 antibody; PAM18 antibody; TIM 14 antibody; TIM14 antibody; TIM14_HUMAN antibody; TIMM 14 antibody; TIMM14 antibody; translocase of the inner mitochondrial membrane 14 antibody; Translocase of the inner mitochondrial membrane 14; yeast homolog of antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DNAJC19
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling. May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity.
  • 基因功能参考文献：
    1. Both DnaJC15 and DnaJC19 formed two distinct subcomplexes with Magmas at the import channel. PMID: 27330077
    2. The loss of DNAJC19/PHB complexes affects cardiolipin acylation and leads to the accumulation of cardiolipin species with altered acyl chains. PMID: 24856930
    3. A report of a new mutation in the human DNAJC19 gene that causes early onset dilated cardiomyopathy syndrome in two brothers of Finnish origin. PMID: 22797137
    4. The association of dilated cardiomyopathy with ataxia (DCMA) syndrome with a segment of 3q26.33 and the identification of a splice mutation in a novel gene DNAJC19 in DCMA patients. PMID: 16055927
    5. Dilated cardiomyopathy caused by homozygous mutations in a novel gene, DNAJC19, presumed to play a role in importation of mitochondrial proteins. PMID: 17244376

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  • 相关疾病：
    3-methylglutaconic aciduria 5 (MGA5)
  • 亚细胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
  • 蛋白家族：
    TIM14 family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 30528

    OMIM: 608977

    KEGG: hsa:131118

    STRING: 9606.ENSP00000372005

    UniGene: Hs.230601